Výsledky vyhledávání - "María Rodríguez-Mata"

Baeyer-Villiger monooxygenase-catalyzed desymmetrizations of cyclobutanones. Application to the synthesis of valuable spirolactones

Autor: Vicente Gotor, Javier Mendiola, Ivan Collado, Oscar de Frutos, Susana García-Cerrada, Vicente Gotor-Fernández, Iván Lavandera, María Rodríguez-Mata

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

A series of γ-butyrolactone derivatives, including some spiranic ones, was obtained through desymmetrization of the corresponding prochiral 3-substituted cyclobutanones via Baeyer–Villiger monooxygenase (BVMO)-catalyzed oxidation. After reaction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30205949d317d5d97f7374a710d6a317
http://hdl.handle.net/10651/37086

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Stereoselective Chemoenzymatic Preparation of β-Amino Esters: Molecular Modelling Considerations in Lipase-Mediated Processes and Application to the Synthesis of (S)-Dapoxetine

Autor: Vicente Gotor-Fernández, María Rodríguez-Mata, Eduardo García-Urdiales, Vicente Gotor

Publikováno v: Advanced Synthesis & Catalysis. 352:395-406

A wide range of optically active 3-amino-3-arylpropanoic acid derivatives have been prepared by means of a stereoselective chemoenzymatic route. The key step is the kinetic resolution of the corresponding β-amino esters. Although the enzymatic acyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b782e311275a2029e5f9bf76c78d5dfa
https://doi.org/10.1002/adsc.200900676

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Chemoenzymatic Synthesis of Rivastigmine Based on Lipase-Catalyzed Processes

Autor: Juan Mangas-Sanchez, Eduardo Busto, Vicente Gotor-Fernández, María Rodríguez-Mata, Vicente Gotor

Publikováno v: The Journal of Organic Chemistry. 74:5304-5310

A straightforward chemoenzymatic synthesis of enantiomerically pure rivastigmine has been efficiently carried out under mild reaction conditions, with Candida antarctica lipase B responsible for the stereoselective acetylation of the corresponding (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140709b5c1f192d375c5cbe613d1e1f7
https://doi.org/10.1021/jo900784g

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Efficient access to enantiomerically pure cyclic α-amino esters through a lipase-catalyzed kinetic resolution

Autor: Carlos Cativiela, Vicente Gotor-Fernández, Ana I. Jiménez, Francisco J. Sayago, María Rodríguez-Mata, Marcos Carlos de Mattos, Sergio Alatorre-Santamaría, Vicente Gotor

Publikováno v: Tetrahedron: Asymmetry. 19:1714-1719

A series of alpha-amino acid derivatives containing the 2,3-dihydroindole or octahydroindole core have been chemoenzymatically synthesized in good overall yields and high enantiomeric purity under mild reaction conditions using lipases for the introd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9814bee33e14ae9c2ff87f8b4ed40ba7
https://doi.org/10.1016/j.tetasy.2008.06.010

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Lactonization reactions through hydrolase-catalyzed peracid formation. Use of lipases for chemoenzymatic Baeyer-Villiger oxidations of cyclobutanones

Autor: Vicente Gotor-Fernández, Vicente Gotor, María Rodríguez-Mata, Daniel Méndez-Sánchez, Daniel González-Martínez

Publikováno v: WOS:000353849600006
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

A one-pot chemoenzymatic method has been described for the synthesis of γ-butyrolactones starting from the corresponding ketones through a Baeyer–Villiger reaction. The approach is based on a lipase-catalyzed perhydrolysis for the formation of per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ad4518d95ee06df70170b13763ac25
http://hdl.handle.net/10651/33565

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Enzymatic and chromatographic resolution procedures applied to the synthesis of the phosphoproline enantiomers

Autor: Vicente Gotor-Fernández, Ana I. Jiménez, María Jesús Pueyo, Vicente Gotor, María Rodríguez-Mata, Alicia Arizpe, Carlos Cativiela, Francisco J. Sayago

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC

The preparation of enantiomerically pure pyrrolidine-2-phosphonic acid (phosphoproline, Pro) has been addressed through the synthesis of suitable racemates and subsequent resolution by independent enzyme-catalyzed and chiral HPLC methods. First, race

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2496d0d6bb26726f00e0254ff50d46
http://hdl.handle.net/10651/36408

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Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines

Autor: Susana García-Cerrada, Oscar de Frutos, Caroline E. Paul, Javier Mendiola, Iván Lavandera, Eduardo Busto, Vicente Gotor-Fernández, Ivan Collado, María Rodríguez-Mata, Vicente Gotor

Publikováno v: WOS:000337870900016
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Critical parameters affecting the stereoselective amination of (hetero)aromatic ketones using transaminases have been studied, such as temperature, pH, substrate concentration, cosolvent, and source and percentage of amino donor, to further optimize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e1919965ab2cc1835737d4013b7cd0
http://hdl.handle.net/10651/32972

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Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate

Autor: María Rodríguez‐Mata, Annika Frank, Elizabeth Wells, Friedemann Leipold, Nicholas J. Turner, Gideon Grogan, Johan P. Turkenburg, Sam Hart

Publikováno v: ChemBioChem

NADPH-dependent oxidoreductase Q1EQE0 from Streptomyces kanamyceticus catalyzes the asymmetric reduction of the prochiral monocyclic imine 2-methyl-1-pyrroline to the chiral amine (R)-2-methylpyrrolidine with >99% ee, and is thus of interest as a pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee57991a1c1c702f1a4618705c0fe7f0
https://pubmed.ncbi.nlm.nih.gov/23813853

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2-Propanone,O-[(ethenyloxy)carbonyl]oxime

Autor: María Rodríguez-Mata, Vicente Gotor-Fernández, Vicente Gotor

Publikováno v: e-EROS Encyclopedia of Reagents for Organic Synthesis

[139705-38-7] C6H9NO3 (MW 143.14) InChI = 1S/C6H9NO3/c1-4-9-6(8)10-7-5(2)3/h4H,1H2,2-3H3 InChIKey = DNFOKRIHYIUHBR-UHFFFAOYSA-N (reagent used for the monofunctionalization of polyalcohol molecules through lipase-catalyzed processes) Alternative Names

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d3a0935c707dfe1be87607cf78abcf7
https://doi.org/10.1002/047084289x.rn01396

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Straightforward preparation of biologically active 1-aryl- and 1-heteroarylpropan-2-amines in enantioenriched form

Autor: Francisca Rebolledo, María Rodríguez-Mata, Vicente Gotor, Javier González-Sabín, Vicente Gotor-Fernández

Publikováno v: Organicbiomolecular chemistry. 9(7)

Because of the importance of developing stereoselective syntheses for single enantiomers, a selected panel of racemic biologically active 1-aryl- and 1-heteroarylpropan-2-amines has been prepared, followed by a study of their behavior in enzymatic ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc0f53656e577a43fcddc959bd4b81e
https://pubmed.ncbi.nlm.nih.gov/21308130

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