Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization

Autor: María Pimentel-Santillana, Paqui G. Través, Raquel Pérez-Sen, Esmerilda G. Delicado, Paloma Martín-Sanz, María Teresa Miras-Portugal, Lisardo Boscá

Publikováno v: Mediators of Inflammation, Vol 2014 (2014)

The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types. These rece

Externí odkaz: https://doaj.org/article/103443025af84c7ea95c9175cf92240c

Anti-inflammatory Actions of Acanthoic Acid-Related Diterpenes Involve Activation of the PI3K p110γ/δ Subunits and Inhibition of NF-κB

Autor: Paqui G. Través, Antonio Castrillo, Nuria Rodriguez, Emmanuel A. Theodorakis, Daniel Rico, Paloma Martín-Sanz, Michael A. Palladino, María Pimentel-Santillana, Thomas Miethke, Lisardo Boscá

Publikováno v: Chemistry & biology, vol 21, iss 8
Través, PG; Pimentel-Santillana, M; Rico, D; Rodriguez, N; Miethke, T; Castrillo, A; et al.(2014). Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB. Chemistry & biology, 21(8), 955-966. doi: 10.1016/j.chembiol.2014.06.005. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3n0270nz
Digital.CSIC. Repositorio Institucional del CSIC
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Través, PG; Pimentel-Santillana, M; Rico, D; Rodriguez, N; Miethke, T; Castrillo, A; et al.(2014). Anti-inflammatory Actions of Acanthoic Acid-Related Diterpenes Involve Activation of the PI3K p110γ/δ Subunits and Inhibition of NF-κB. Chemistry and Biology. doi: 10.1016/j.chembiol.2014.06.005. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9gt3z9j4

et al.
The effect of acanthoic acid analogs on the response to proinflammatory challenge was investigated. Some pimarane diterpenes are known activators of the LXRαβ nuclear receptors, but we show here that they also exert a rapid, potent, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528901e779438c9db01543d30819a8cd
https://doi.org/10.1016/j.chembiol.2014.06.005

Relevance of the MEK/ERK Signaling Pathway in the Metabolism of Activated Macrophages: A Metabolomic Approach

Autor: Silvia Marin, Lisardo Boscá, Pedro de Atauri, Paloma Martín-Sanz, María Pimentel-Santillana, Juan-Carlos Rodríguez-Prados, Paqui G. Través, Marta Cascante, Igor Marín de Mas, Vitaly A. Selivanov

Publikováno v: The Journal of Immunology. 188:1402-1410

The activation of immune cells in response to a pathogen involves a succession of signaling events leading to gene and protein expression, which requires metabolic changes to match the energy demands. The metabolic profile associated with the MAPK ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449f603cd4958d6b9f3b1bb1bdb48b1c
https://doi.org/10.4049/jimmunol.1101781

The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system

Autor: Esmerilda G. Delicado, María Teresa Miras-Portugal, Rosa Gómez-Villafuertes, María Pimentel-Santillana, Paula García-Huerta, Miguel Díaz-Hernández

Publikováno v: The Journal of Biological Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname

P2X7 receptors are involved not only in physiological functions but also in pathological brain processes. Although an increasing number of findings indicate that altered receptor expression has a causative role in neurodegenerative diseases and cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c2ee31f878dc3269c0f8457453875c
http://hdl.handle.net/10261/78033

Metabolomic analysis of macrophage activation and relevance of the cross-talk between energetic metabolism and polarized gene expression (172.12)

Autor: Lisardo Bosca, Paqui Través, María Pimentel-Santillana, Pedro de Atauri, Silvia Marin, Marta Cascante

Publikováno v: The Journal of Immunology. 188:172.12-172.12

Immune activation rapidly and substantially enhances metabolic outputs. Macrophage activation is followed by rapid changes in nutrient flux, which also seems to be necessary for immune activation, indicating that signals produced by immune cells migh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e044991ba940ceab1f9a4eed23c7581
https://doi.org/10.4049/jimmunol.188.supp.172.12