Výsledky vyhledávání - "María Orera"

Akademický článek

A collection of three integration-free iPSCs derived from old male and female healthy subjects

Autor: Eva Rodríguez-Traver, Eva Díaz-Guerra, César Rodríguez, Fabián Arenas, María Orera, Jaime Kulisevsky, Rosario Moratalla, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 42, Iss , Pp - (2020)

Here, we present the characterization of three iPSC lines derived from dermal fibroblasts of old healthy subjects. Fibroblasts were reprogrammed using Sendai viral vectors encoding OCT4, SOX2, KLF4 and c-MYC. The iPSCs expressed endogenous pluripoten

Externí odkaz: https://doaj.org/article/e58cf9e4b1094feba1c6a7e26ec7c849

Zobrazit plný text záznamu

Akademický článek

An integration-free iPSC line, ICCSICi007-A, derived from a female Alzheimer's disease patient with the APOE-ε4/ε4 alleles

Autor: Eva Díaz-Guerra, Eva Rodríguez-Traver, Elena P. Moreno-Jiménez, Itziar de Rojas, César Rodríguez, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 41, Iss , Pp - (2019)

The epsilon4 (ε4) allele of the APOE gene, which encodes the apolipoprotein E4 (ApoE4), is the strongest genetic risk factor known for late-onset Alzheimer´s disease (LOAD). Here, we present the characterization of an iPSC line generated from derma

Externí odkaz: https://doaj.org/article/ab385c0261d1499db8825e7cd7e9ab7c

Zobrazit plný text záznamu

Akademický článek

Generation of an integration-free iPSC line, ICCSICi006-A, derived from a male Alzheimer's disease patient carrying the PSEN1-G206D mutation

Autor: Eva Díaz-Guerra, Manuel A. Oria-Muriel, Elena P. Moreno-Jiménez, Itziar de Rojasb,, César Rodríguez, Eva Rodríguez-Traver, María Orera, Isabel Hernándezb,, Agustín Ruizb,, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 40, Iss , Pp - (2019)

The familial form of Alzheimer's disease (FAD), which is caused by mutations in PRESENILIN 1 (PSEN1) and amyloid precursor protein (APP) genes, represents less than 5% of all AD cases and has an early-onset. We report the generation and characterizat

Externí odkaz: https://doaj.org/article/dbb39638ed824d1c901ae2f5464bc1fd

Zobrazit plný text záznamu

Akademický článek

Generation of an integration-free iPSC line, ICCSICi005-A, derived from a Parkinson's disease patient carrying the L444P mutation in the GBA1 gene

Autor: Eva Rodríguez-Traver, César Rodríguez, Eva Díaz-Guerra, Fabián Arenas, Marcos Araúzo-Bravo, María Orera, Jaime Kulisevsky, Rosario Moratalla, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 40, Iss , Pp - (2019)

The L444P mutation in the GBA1 gene which encodes β-glucocerebrosidase-1, is a major risk factor for developing Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We report the generation and characterization of an induced pluripotent ste

Externí odkaz: https://doaj.org/article/53bbc8ce3478446488cf6b190cc7d98c

Zobrazit plný text záznamu

Akademický článek

A collection of four integration-free iPSC lines derived from diagnosed sporadic Alzheimer's disease patients with different APOE alleles

Autor: Eva Díaz-Guerra, Elena P. Moreno-Jiménez, Itziar de Rojas, César Rodríguez, Eva Rodríguez-Traver, Esther Arribas-González, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 39, Iss , Pp - (2019)

Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to late-onset Alzheimer's disease (LOAD). The ε3 allele of APOE, the most common isoform, does not represent a risk factor for LOAD. In contrast, the ε4 allele is t

Externí odkaz: https://doaj.org/article/8e2f1789e21148eebc02e9b45ee6d12f

Zobrazit plný text záznamu

Akademický článek

A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene

Autor: Eva Rodríguez-Traver, Eva Díaz-Guerra, César Rodríguez, Pablo Fernández, Fabián Arenas, Marcos Araúzo-Bravo, María Orera, Jaime Kulisevsky, Rosario Moratalla, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 38, Iss , Pp - (2019)

Mutations in the GBA1 gene, which encodes the lysosomal enzyme Glucocerebrosidase1 are major risk factors for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We have generated induced pluripotent stem cells (iPSCs) from fibroblasts of f

Externí odkaz: https://doaj.org/article/18dcdd896cdc4642899f1595d1509c59

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Oncología personalizada: principales biomarcadores en el pronóstico y tratamiento de tumores sólidos

Autor: María Concepción Alonso-Cerezo, Gema María Varo Sánchez, Emilio José Laserna Mendieta, Marta Molina Romero, María Orera Clemente

Publikováno v: Revista del Laboratorio Clínico. 12:e1-e8

Resumen En las ultimas decadas ha habido grandes avances en los tratamientos personalizados en pacientes oncologicos gracias a un importante desarrollo cientifico. El analisis genomico ha mostrado que tumores que parecian tener un origen comun, en re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6db554745cb653c55bf9e73aea67fa28
https://doi.org/10.1016/j.labcli.2018.11.001

Zobrazit plný text záznamu

Precision medicine in clinical laboratories in Spain: results from a survey addressed to Laboratory Medicine specialists

Autor: Rufino Mondéjar García, Pilar Sanz Martín, Emilio José Laserna Mendieta, María Orera Clemente, Marta Molina Romero, Gema María Varo Sánchez

Publikováno v: Revista de Medicina de Laboratorio.

EnglishIntroduction: precision medicine (PM) has become a reality in clinical practice, however implementation of this approach is challenging due to their novelty and the highly-specialized knowledge required. Our aim is to describe the situation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd76a8b4cc5f28ded36329a25b25fbb1
https://doi.org/10.20960/revmedlab.00034

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání