Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities

Autor: Gloria Pastor-Fernández, Isabel R. Mariblanca, María N. Navarro

Publikováno v: Cells, Vol 9, Iss 9, p 2044 (2020)

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis, or rheumatoid arthritis. The pathological consequences of excessive

Externí odkaz: https://doaj.org/article/05da84e9d5b049709402593e1e3297b7

Mutation of the Polyproline Sequence in CD3ε Evidences TCR Signaling Requirements for Differentiation and Function of Pro-Inflammatory Tγδ17 Cells

Autor: Aldo Borroto, Balbino Alarcón, María N. Navarro

Publikováno v: Frontiers in immunology. 13

Tγδ17 cells have emerged as a key population in the development of inflammatory and autoimmune conditions such as psoriasis. Thus, the therapeutic intervention of Tγδ17 cells can exert protective effects in this type of pathologies. Tγδ cells c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8239f783018bf853d905ac529879681
https://pubmed.ncbi.nlm.nih.gov/35432331

Galectin-1 expression in CD8+ T lymphocytes controls inflammation in contact hypersensitivity

Autor: Raquel Castillo-González, Hortensia de la Fuente, Francisco Sánchez-Madrid, María Laura Saiz, Manuel Fresno, Nieves Fernández-Gallego, Marta Ramírez-Huesca, María N. Navarro, Danay Cibrian

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Allergic contact dermatitis, also known as contact hypersensitivity, is a frequent T-cell‒mediated inflammatory skin disease characterized by red, itchy, swollen, and cracked skin. It is caused by the direct contact with an allergen and/or irritant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddfb1ad274e1ba73d00c47bc4746cc7
https://doi.org/10.1016/j.jid.2020.10.020

IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics

Autor: Jesús Pino, Gloria Pastor-Fernández, Candelas Álvarez-Salamero, Raquel Castillo-González, María N. Navarro, Danay Cibrian, Isabel R. Mariblanca

Publikováno v: PLoS Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
PLoS Biology, Vol 18, Iss 3, p e3000646 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

Interleukin 23 (IL-23) triggers pathogenic features in pro-inflammatory, IL-17-secreting T cells (Th17 and Tγδ17) that play a key role in the development of inflammatory diseases. However, the IL-23 signaling cascade remains largely undefined. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af66198438fdf3e03f27d0c43e952278
http://europepmc.org/articles/PMC7117768

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Autor: Victoria H. Cowling, Jens L. Hukelmann, Doreen A. Cantrell, Gavin C. Preston, Aneesa Kaskar, Linda V. Sinclair, H. Robson MacDonald, María N. Navarro, Isabel Ferrero

Publikováno v: The EMBO Journal
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
EMBO Journal, vol. 34, no. 15, pp. 2008-2024
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b236e1c8823366a75e0e55d2b3306ae
http://europepmc.org/articles/PMC4551349