NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl

Autor: Mariángeles, Clauzure, Ángel G, Valdivieso, Andrea V, Dugour, Consuelo, Mori, María M, Massip-Copiz, María Á, Aguilar, Verónica, Sotomayor, Cristian J A, Asensio, Juan M, Figueroa, Tomás A, Santa-Coloma

Publikováno v: Immunology

The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity induces intracellular chloride (Cl(–)) accumulation. The anion Cl(–), acting as a second messenger, stimulates the secretion of interleukin‐1β (IL‐1β)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afe30d4e712b4a464e6ddc05e5cea28e
https://pubmed.ncbi.nlm.nih.gov/33835494

CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells

Autor: Camila Falduti, Tomás A. Santa-Coloma, Ángel G. Valdivieso, Rocío García, Raquel Jara, Mariángeles Clauzure, María M. Massip-Copiz, María Á. Aguilar

Publikováno v: International Journal of Biochemistry and Cell Biology, Vol. 135, 105976, 2021
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Fil: García Solcá, Rocío. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina Fil: García Solcá, Rocío. Consejo Nacional de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00f741d84236988b83d64235b74cf1f
https://repositorio.uca.edu.ar/handle/123456789/14597

The mitochondrial complex I activity is reduced in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.

Autor: Angel G Valdivieso, Mariángeles Clauzure, María C Marín, Guillermo L Taminelli, María M Massip Copiz, Francisco Sánchez, Gustavo Schulman, María L Teiber, Tomás A Santa-Coloma

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48059 (2012)

Cystic fibrosis (CF) is a frequent and lethal autosomal recessive disease. It results from different possible mutations in the CFTR gene, which encodes the CFTR chloride channel. We have previously studied the differential expression of genes in CF a

Externí odkaz: https://doaj.org/article/30c5dfba9f9f4babbffaf3c44fc5646a

Impairment of CFTR activity in cultured epithelial cells upregulates the expression and activity of LDH resulting in lactic acid hypersecretion

Autor: Mariángeles Clauzure, María M. Massip-Copiz, Cristian J. A. Asensio, Carla E. Cancio, Consuelo Mori, Tomás A. Santa-Coloma, Ángel G. Valdivieso

Publikováno v: Cellular and Molecular Life Sciences. 2019, 76
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Mutations in the gene encoding the CFTR chloride channel produce cystic fbrosis (CF). CF patients are more susceptible to bacterial infections in lungs. The most accepted hypothesis sustains that a reduction in the airway surface liquid (ASL) volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382cfef6734e5ef1deebbc9953f5c6d9
https://repositorio.uca.edu.ar/handle/123456789/9596

Extracellular pH and lung infections in cystic fibrosis

Autor: Tomás A. Santa-Coloma, María M. Massip-Copiz

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
European Journal of Cell Biology. 2018;97(6):402-410
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Fil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina Fil: Massip Copiz, María Macarena. Conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e878654fba11008652ab320704713
https://www.sciencedirect.com/science/article/pii/S0171933518301481