The TLR4-MyD88 Signaling Axis Regulates Lung Monocyte Differentiation Pathways in Response to Streptococcus pneumoniae

Autor: Rodrigo Sánchez-Tarjuelo, Isabel Cortegano, Juliana Manosalva, Mercedes Rodríguez, Carolina Ruíz, Mario Alía, María Carmen Prado, Eva M. Cano, María José Ferrándiz, Adela G. de la Campa, María Luisa Gaspar, Belén de Andrés

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Streptococcus pneumoniae is the main cause of bacterial pneumonia, a condition that currently produces significant global morbidity and mortality. The initial immune response to this bacterium occurs when the innate system recognizes common motifs ex

Externí odkaz: https://doaj.org/article/a1e658d49c294935a0963c7bbcb0207f

Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

Autor: Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Melania Guerrero-Hue, Cristina García-Caballero, Carmen Herencia, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Pablo Cannata, Isabel Cortegano, Belén de Andrés, María Luisa Gaspar, Susana Cadenas, Patrycja Michalska, Rafael León, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We inv

Externí odkaz: https://doaj.org/article/db9f163feba548e684515e2a31a59e8a

Supplementary Figure S6 from Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing

Autor: Javier García-Castro, María-Luisa Gaspar, Belén de Andrés, Teresa Cejalvo, Stefano Gambera, Miguel Ángel Rodriguez-Milla, Alvaro Morales-Molina

OAd-MSC WT and OAd-MSC TLR4−/− show similar expression of cell membrane receptors in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b3a90bdea7a868749e3c5134a8507
https://doi.org/10.1158/2767-9764.22546928.v1

Data from Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing

Autor: Javier García-Castro, María-Luisa Gaspar, Belén de Andrés, Teresa Cejalvo, Stefano Gambera, Miguel Ángel Rodriguez-Milla, Alvaro Morales-Molina

Cancer immunotherapy aims to activate the immune system. Some immunotherapeutic agents can be loaded in carrier cells for delivering to the tumors. However, a challenge with cell-based therapies is the selection of the appropriate cells to produce ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1647c5eb47c1e2d1972e01fd4b26a24e
https://doi.org/10.1158/2767-9764.c.6551258

TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis

Autor: Samuel M. Gonçalves, B de Andres, María Luisa Gaspar, Leticia Bernal-Martinez, Agostinho Carvalho, J Maertens, Emilia Mellado, Laura Alcazar-Fuoli, Cristina Cunha, Katrien Lagrou, I Gonzalez Jimenez

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Virulence
article-version (VoR) Version of Record
Virulence, Vol 12, Iss 1, Pp 570-583 (2021)

Pattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d105200be5d1f8d14b88e54a1ffc13f
https://doi.org/10.1080/21505594.2021.1879471