Zobrazeno 1 - 10 of 28 pro vyhledávání: '"María L. Orea"'
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Akademický článek
Chiral Indolizinium Salts Derived from 2-Pyridinecarbaldehyde—First Diastereoselective Syntheses of (−)-1-epi-lentiginosine
Autor: Hisami Rodriguez-Matsui, David M. Aparicio, María L. Orea, Jorge R. Juárez, Victor Gómez-Calvario, Dino Gnecco, Alan Carrasco-Carballo, Joel L. Terán
Publikováno v: Molecules, Vol 28, Iss 9, p 3719 (2023)
The first diastereoselective synthesis of (−)-1-epi-lentiginosine from a common chiral trans-epoxyamide derived from 2-pyridincarbaldehyde is reported. This methodology involves a sequential oxirane ring opening and intramolecular 5-exo-tet cycliza
Externí odkaz: https://doaj.org/article/383fae4146db46d29e1ea046079349d2
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2
β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
Autor: Carrasco-Carballo, Roberto A. Galeana-Ascencio, Liliana Mendieta, Daniel I. Limon, Dino Gnecco, Joel L. Terán, María L. Orea, Alan
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8164
The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer’s disease (AD). The inhibition of BACE-1 has been an important pharmacological strategy in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d30356c823170009003694aa5fd7c9b5
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3
Chiral Indolizinium Salts Derived from 2-Pyridinecarbaldehyde. First Diastereoselective Syntheses of (–)-1-Epi-Lentiginosine
Autor: Hisami Rodriguez-Matsui, David M. Aparicio, María L. Orea, Jorge R. Juárez, Victor Gómez-Calvario, Dino Gnecco, Alan Carrasco-Carballo, And Joel L. Terán
The first diastereoselective synthesis of (–)-1-epi-lentiginosine stars from a common chiral trans-epoxyamide derived from 2-pyridincarbaldehyde is reported. This methodology involves a sequential oxirane ring opening and intramolecular 5-exo-tet c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620829c33462a36addc541d2b56ca301
https://doi.org/10.20944/preprints202304.0188.v1
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5
β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
Autor: Roberto A. Galeana-Ascencio, Liliana Mendieta, Daniel I. Limon, Dino Gnecco, Joel L. Terán, María L. Orea, Alan Carrasco-Carballo
Publikováno v: International Journal of Molecular Sciences. 24:8164
The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer’s disease (AD). The inhibition of BACE-1 has been an important pharmacological strategy in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1418a34d21424448f632f84057c40374
https://doi.org/10.3390/ijms24098164
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7
Stereoconvergent synthesis of N-Boc-(2R,3S)-3-hydroxy-2-phenylpiperidine
Autor: Sylvain Bernès, Manuel Velasco, Ulises Hernández, Jorge R. Juárez, María L. Orea, Dino Gnecco, Joel L. Terán, Víctor Gómez-Calvario, David M. Aparicio
Publikováno v: Tetrahedron Letters. 60:820-824
The stereoconvergent synthesis of N-Boc-(2R,3S)-3-hydroxy-2-phenylpiperidine from (R)-1-(2-((tert-butyldimethylsilyl)oxy)-1-phenylethyl)piperidin-2-one is described. The key steps involved are α-hydroxylation of quiral lactam with O2, stereoconverge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85541caf9a0739b133a5bcd2bc32e18f
https://doi.org/10.1016/j.tetlet.2019.02.005
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9
Synthesis of (+)- and (−)-Geissman-Waiss lactone from chiral sulfonium salts
Autor: Ricardo López-González, María L. Orea, Dino Gnecco, Sylvain Bernès, Joel L. Terán, Jorge R. Juárez, David M. Aparicio, Víctor Gómez-Calvario
Publikováno v: Tetrahedron Letters. 61:151697
A novel series of chiral cyclic zwitterionic pyrrolidinone type intermediates was prepared via regioselective 5-exo-trig-ring-closure of the corresponding chiral sulfonium salts. This synthetic strategy allowed the rapid non-racemic synthesis of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d413cb5ac5c5bd9d03c5aa162b152098
https://doi.org/10.1016/j.tetlet.2020.151697
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