Zobrazeno 1 - 10
of 270
pro vyhledávání: '"María L. Martínez"'
Autor:
Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100918- (2024)
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteris
Externí odkaz:
https://doaj.org/article/2c731ca37cd542a581f44cda78d386a6
Autor:
Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa Cardoso Delgado, Felix Elortza, Jesús Jiménez-Barbero, Ruben Nogueiras, Vincent Prevot, Asis Palazon, María L. Martínez-Chantar
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
SARS-CoV-2 pseudovirus infects human hepatocytes leading to metabolic reprogramming towards glycolysis and impaired mitochondrial activity, and metformin can reduce infection under steatotic conditions.
Externí odkaz:
https://doaj.org/article/3f2d0b36718146559a8c005f572704c4
Autor:
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Externí odkaz:
https://doaj.org/article/679efae112224ba6a2829203d49df6dc
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role. Several studies revealed that nitrogen metabolism is altered in Metabolic
Externí odkaz:
https://doaj.org/article/2599761a436f4211b50a0216bf47a6fd
Autor:
Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, Laura Vila-Vecilla, Samanta Romina Zanetti, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Ander de Blas, Paloma Velasco-Beltrán, Marina Serrano-Maciá, Paula Iruzubieta, Majid Mehrpouyan, Edward M. Goldberg, Scott J. Bornheimer, Nieves Embade, María L. Martínez-Chantar, Marcos López-Hoyos, José M. Mato, Óscar Millet, Asís Palazón
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccines against SARS-CoV-2 have alleviated infection rates, hospitalization and deaths associated with COVID-19. In order to monitor humoral immunity, several serology tests have been developed, but the recent emergence of variants of concern has re
Externí odkaz:
https://doaj.org/article/f1a79275891c4ccc8b0bee29864100b3
Autor:
Pablo Fernández-Tussy, Rubén Rodríguez-Agudo, David Fernández-Ramos, Lucía Barbier-Torres, Imanol Zubiete-Franco, Sergio López de Davalillo, Elisa Herraez, Naroa Goikoetxea-Usandizaga, Sofia Lachiondo-Ortega, Jorge Simón, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de Juan, Misti V. McCain, Maria J. Perugorria, Jon Mabe, Nicolás Navasa, Cecilia M. P. Rodrigues, Isabel Fabregat, Loreto Boix, Victor Sapena, Juan Anguita, Shelly C. Lu, José M. Mato, Jesus M. Banales, Erica Villa, Helen L. Reeves, Jordi Bruix, Maria Reig, Jose J. G. Marin, Teresa C. Delgado, María L. Martínez-Chantar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)
Abstract Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma (HCC), although the
Externí odkaz:
https://doaj.org/article/fb7ef154614446039d3b36ccb14472c8
Autor:
Pablo Fernández-Tussy, David Fernández-Ramos, Fernando Lopitz-Otsoa, Jorge Simón, Lucía Barbier-Torres, Beatriz Gomez-Santos, Maitane Nuñez-Garcia, Mikel Azkargorta, Virginia Gutiérrez-de Juan, Marina Serrano-Macia, Rubén Rodríguez-Agudo, Paula Iruzubieta, Juan Anguita, Rui E. Castro, Devin Champagne, Mercedes Rincón, Felix Elortza, Anita Arslanow, Marcin Krawczyk, Frank Lammert, Mélanie Kirchmeyer, Iris Behrmann, Javier Crespo, Shelly C. Lu, José M. Mato, Marta Varela-Rey, Patricia Aspichueta, Teresa C. Delgado, María L. Martínez-Chantar
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 40-54 (2019)
Objective: Non-alcoholic fatty liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead to lipid accumulation and pro
Externí odkaz:
https://doaj.org/article/a17e13bf601849f78b91e8ef169b6cb2
Autor:
José M. García-Domínguez, Jorge Maurino, María L. Martínez-Ginés, Olga Carmona, Ana B. Caminero, Nicolás Medrano, Elena Ruíz-Beato, for the W-IMPACT Clinical Investigators
Publikováno v:
BMC Public Health, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background In multiple sclerosis (MS), half of affected people are unemployed within 10 years of diagnosis. The aim of this study was to assess the economic impact of MS in adult subjects with relapsing-remitting MS (RRMS) and primary progre
Externí odkaz:
https://doaj.org/article/fce32b1910384a4b842c112c4f7520e9
Autor:
Imanol Zubiete-Franco, Juan L. García-Rodríguez, Fernando Lopitz-Otsoa, Marina Serrano-Macia, Jorge Simon, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Virginia Gutiérrez-de-Juan, Sergio López de Davalillo, Onintza Carlevaris, Adolfo Beguiristain Gómez, Erica Villa, Diego Calvisi, César Martín, Edurne Berra, Patricia Aspichueta, Naiara Beraza, Marta Varela-Rey, Matias Ávila, Manuel S. Rodríguez, José M. Mato, Irene Díaz-Moreno, Antonio Díaz-Quintana, Teresa C. Delgado, María L. Martínez-Chantar
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 406-421 (2019)
Background: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC). Methods: Herei
Externí odkaz:
https://doaj.org/article/e999866377054581b7ff898019281bf5
Autor:
María V. Rodriguez, Josefina Tano, Nazarena Ansaldi, Analía Carrau, María S. Srebot, Virginia Ferreira, María L. Martínez, Adriana A. Cortadi, María I. Siri, Elena G. Orellano
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Nowadays, fertilization and pest control are carried out using chemical compounds that contaminate soil and deteriorate human health. Plant growth promoting bacteria endophytes (PGPBEs), are a well-studied group of bacteria that offers benefits to th
Externí odkaz:
https://doaj.org/article/2af016986c8f41649ccfe665e4130e45