Výsledky vyhledávání - "María L. Gil-Cardeza"

Interferon-β gene transfer induces a strong cytotoxic bystander effect on melanoma cells

Autor: Liliana M.E. Finocchiaro, María L. Gil-Cardeza, Úrsula A. Rossi, Marcela Solange Villaverde, Gerardo Claudio Glikin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived from three human cutane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd1e7086edfa6d9b434299fcd5eed8
https://doi.org/10.1016/j.biopha.2015.04.002

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Interferon-β lipofection I. Increased efficacy of chemotherapeutic drugs on human tumor cells derived monolayers and spheroids

Autor: María L. Gil-Cardeza, Gerardo Claudio Glikin, Marcela Solange Villaverde, Liliana Maria Elena Finocchiaro

Publikováno v: Cancer Gene Therapy. 19:508-516

We evaluated the effect of hIFNβ gene transfer alone or in combination with different antineoplastic drugs commonly used in cancer treatment. Five human tumor-derived cell lines were cultured as monolayers and spheroids. Four cell lines (Ewing sarco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559d62705ad6992f3f27c696224e63e4
https://doi.org/10.1038/cgt.2012.27

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Interferon-β lipofection II. Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-β gene transfer to human tumor cells

Autor: María L. Gil-Cardeza, Marcela Solange Villaverde, Liliana Maria Elena Finocchiaro, Gerardo Claudio Glikin

Publikováno v: Cancer Gene Therapy. 19:420-430

We evaluated the cytotoxic effects (apoptosis, necrosis and early senescence) of human interferon-β (hIFNβ) gene lipofection. The cytotoxicity of hIFNβ gene lipofection resulted equivalent to that of the corresponding addition of the recombinant p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e20ffc7fabac0603db8288850cafb7
https://doi.org/10.1038/cgt.2012.19

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Cytokine-enhanced vaccine and interferon-β plus suicide gene as combined therapy for spontaneous canine sarcomas

Autor: María L. Gil-Cardeza, Liliana M.E. Finocchiaro, Marcela Solange Villaverde, Gerardo Claudio Glikin, María D. Riveros

Publikováno v: Research in Veterinary Science. 91:230-234

Eleven soft tissue- and five osteosarcoma canine patients were subjected to: (i) periodic subcutaneous injection of irradiated xenogeneic cells secreting hGM-CSF and hIL-2 mixed with allogeneic or autologous tumor homogenates; and (ii) injections of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47025218fff41afc139d4ef899df4d3f
https://doi.org/10.1016/j.rvsc.2010.12.012

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Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro

Autor: Liliana Maria Elena Finocchiaro, N A Altamirano, Gerardo Claudio Glikin, Marcela Solange Villaverde, Gabriel L. Fiszman, María L. Gil-Cardeza, R A Cwirenbaum

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

To validate the use of multicellular spheroids to predict the efficacy of herpes simplex thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene therapy in the respective in vivo tumors, we established and characterized 15 melanoma-derived cell lines f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c009290dc635fab4335526bc9aec98
https://doi.org/10.1038/gt.2009.107

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Cytokine-Enhanced Vaccine and Interferon-β plus Suicide Gene Therapy as Surgery Adjuvant Treatments for Spontaneous Canine Melanoma

Autor: María L. Gil-Cardeza, María D. Riveros, Liliana Maria Elena Finocchiaro, Úrsula A. Rossi, Marcela Solange Villaverde, Gerardo Claudio Glikin, Chiara Fondello

We present here a nonviral immunogene therapy trial for canine malignant melanoma, an aggressive disease displaying significant clinical and histopathological overlapping with human melanoma. As a surgery adjuvant approach, it comprised the co-inject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785adac48a06c703dfd24baf84a2137
http://online.liebertpub.com/doi/10.1089/hum.2014.130

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Cationic lipid: DNA complexes allow bleomycin uptake by melanoma cells

Autor: Gerardo Claudio Glikin, Marcela Solange Villaverde, Liliana M.E. Finocchiaro, Úrsula A. Rossi, María L. Gil-Cardeza

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Bleomycin is a chemotherapeutic agent barely diffusible through the plasmatic membrane. We evaluated DNA/cationic lipids complexes (lipoplexes) as mediators of its uptake in four spontaneous canine melanoma derived cell lines (Ak, Bk, Br and Rkb). Ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5439316bdea9c047808b9b635a59615
http://www.sciencedirect.com/science/article/pii/S075333221300005X

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