Gender-specific effects of genetic variants within Th1 and Th17 cell-mediated immune response genes on the risk of developing rheumatoid arthritis.

Autor: Rafael Cáliz, Luz María Canet, Carmen Belén Lupiañez, Helena Canhão, Alejandro Escudero, Ileana Filipescu, Juana Segura-Catena, María José Soto-Pino, Manuela Expósito-Ruiz, Miguel Ángel Ferrer, Antonio García, Lurdes Romani, Alfonso González-Utrilla, Teresa Vallejo, Eva Pérez-Pampin, Kari Hemminki, Asta Försti, Eduardo Collantes, João Eurico Fonseca, Juan Sainz

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72732 (2013)

The present study was conducted to explore whether single nucleotide polymorphisms (SNPs) in Th1 and Th17 cell-mediated immune response genes differentially influence the risk of rheumatoid arthritis (RA) in women and men. In phase one, 27 functional

Externí odkaz: https://doaj.org/article/0559e8f486ff437194df03d6c0070656

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Autor: Alfonso González-Utrilla, Alfons A den Broeder, Rafael Cáliz, Juan Sainz, Jose Manuel Sánchez-Maldonado, Romana T. Netea-Maier, Eduardo Collantes-Estevez, Rob ter Horst, María José Soto-Pino, Ana Rodríguez-Ramos, Miguel Ferrer, Yang Li, Marieke J H Coenen, Manuel Martínez-Bueno, Eva Perez-Pampin, Olivier B. Bakker, L. M. Canet, Manuel Jurado, Alejandro Escudero, Mihai G. Netea, João Eurico Fonseca, Juana Segura-Catena, Carmen Belén Lupiañez, Miguel Ángel López Nevot, Helena Canhão, Antonio García

Publikováno v: Scientific Reports, 9:14812. Nature Publishing Group
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Scientific Reports

Here, we assessed whether 41 SNPs within steroid hormone genes associated with erosive disease. The most relevant finding was the rheumatoid factor (RF)-specific effect of the CYP1B1, CYP2C9, ESR2, FcγR3A, and SHBG SNPs to modulate the risk of bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21dd29b3261de56f061be748b3abedb
https://research.rug.nl/en/publications/e560facc-1904-49a4-8d43-85e5c6e256fe

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

Autor: João Eurico Fonseca, Vibeke Andersen, Miguel Ángel López Nevot, Manuel Martínez-Bueno, Federico Canzian, Salvatore De Vita, Rafael Cáliz, Alfons A den Broeder, Antonio García, Sven-Erik Jacobsen, Juana Segura-Catena, Jose Manuel Sánchez-Maldonado, Ana Rodríguez-Ramos, Signe B. Sorensen, Miguel Ferrer, Eduardo Collantes-Estevez, Merete Lund Hetland, Alfonso González-Utrilla, Juan Sainz, Helena Canhão, Pablo Conesa-Zamora, L. M. Canet, I. Filipescu, Carmen Belén Lupiañez, Marieke J H Coenen, María José Soto-Pino, B. Glintborg, Alejandro Escudero, Luca Quartuccio, Eva Perez-Pampin

Publikováno v: Canet, L M, Sánchez-Maldonado, J M, Cáliz, R, Ramos, A R, Lupiañez, C B, Canhão, H, Martínez-Bueno, M, Escudero, A, Segura-Catena, J, Sorensen, S B, Hetland, M L, Soto-Pino, M J, Ferrer, M A, García, A, Glintborg, B, Filipescu, I, Pérez-Pampin, E, González-Utrilla, A, Nevot, M Á L, Conesa-Zamora, P, Broeder, A D, De Vita, S, Jacobsen, S E H, Collantes-Estevez, E, Quartuccio, L, Canzian, F, Fonseca, J E, Coenen, M J H, Andersen, V & Sainz, J 2019, ' Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients ', The Pharmacogenomics Journal, vol. 19, pp. 83-96 . https://doi.org/10.1038/s41397-018-0057-x
Pharmacogenomics Journal, 19, 1, pp. 83-96
Canet, L M, Sánchez-Maldonado, J M, Cáliz, R, Rodríguez-Ramos, A, Lupiañez, C B, Canhão, H, Martínez-Bueno, M, Escudero, A, Segura-Catena, J, Sorensen, S B, Hetland, M L, Soto-Pino, M J, Ferrer, M A, García, A, Glintborg, B, Filipescu, I, Pérez-Pampin, E, González-Utrilla, A, Nevot, M Á L, Conesa-Zamora, P, Broeder, A D, De Vita, S, Jacobsen, S E H, Collantes-Estevez, E, Quartuccio, L, Canzian, F, Fonseca, J E, Coenen, M J H, Andersen, V & Sainz, J 2019, ' Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients ', The Pharmacogenomics Journal, vol. 19, no. 1, pp. 83-96 . https://doi.org/10.1038/s41397-018-0057-x
Pharmacogenomics Journal, 19, 83-96

© Springer Nature Limited 2018
The aim of this case-control study was to evaluate whether 47 single-nucleotide polymorphisms (SNPs) in steroid hormone-related genes are associated with the risk of RA and anti-TNF drug response. We conducted a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a8fdd6bbd1eeec59074f70afbd182e
https://hdl.handle.net/10451/52345

Two-year efficacy of tocilizumab in patients with active rheumatoid arthritis in clinical practice

Autor: Lorena Pérez Albaladejo, Alfonso González Utrilla, Irene Notario Ferreira, Pilar Morales Garrido, María José Soto Pino, Evelyn Suero Rosario, Cristina Caro Hernández, Antonio García Sanchez, Miguel Angel Ferrer González, Rafael Cáliz, Isabel Añón Oñate

Publikováno v: Reumatologia clinica. 13(2)

Objectives To evaluate the efficacy of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) in clinical practice, retention rates of the drug and predictors of response. Methods We performed a descriptive, prospective, longitudinal, open-labe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03e02d1f6965d7e4d09f0d3baa4f12c
https://pubmed.ncbi.nlm.nih.gov/27174398

In vitro activity of β-lactam and non–β-lactam antibiotics in extended-spectrum β-lactamase–producing clinical isolates of Escherichia coli

Autor: María José Soto Pino, Gonzalo Piédrola Angulo, José Gutiérrez Fernández, Antonio Sorlózano Puerto, Juan de Dios Luna del Castillo

Publikováno v: Diagnostic Microbiology and Infectious Disease. 54:135-139

The activity of different beta-lactam and non-beta-lactam antibiotics was assessed against extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing clinical isolates of Escherichia coli. A phenotypic study to discover the presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e410e2cbaf28ddea3ef9ae85482a5
https://doi.org/10.1016/j.diagmicrobio.2005.08.018