Zobrazeno 1 - 10 of 38 pro vyhledávání: '"María José Ruiz-Hidalgo"'
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p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models
Autor: I. Andres, Sebastià Sabater, Marta Ortega-Muelas, Raquel Pascual-Serra, Ricardo Sánchez-Prieto, Elena Arconada-Luque, Borja Belandia, María José Ruiz-Hidalgo, Diego M. Fernández-Aroca, G. Bossi, Natalia García-Flores, Olga Roche
Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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[Background and purpose]: Gemcitabine is an antitumour agent currently used in the treatment of several types of cancer with known properties as a radiosensitizer. p38MAPK signalling pathway has been shown to be a major determinant in the cellular re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8464ddfab7a033d94b9d69332e6f4a68
https://doi.org/10.1016/j.radonc.2020.12.008
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3
Akademický článek
ERK5/BMK1 Is a Novel Target of the Tumor Suppressor VHL: Implication in Clear Cell Renal Carcinoma
Autor: Laura Arias-González, Inmaculada Moreno-Gimeno, Antonio Rubio del Campo, Serrano-Oviedo Leticia, María Llanos Valero, Azucena Esparís-Ogando, Miguel Ángel de la Cruz-Morcillo, Pedro Melgar-Rojas, Jesús García-Cano, Francisco José Cimas, María José Ruiz Hidalgo, Alfonso Prado, Juan Luis Callejas-Valera, Syong Hyun Nam-Cha, José Miguel Giménez-Bachs, Antonio S Salinas-Sánchez, Atanasio Pandiella, Luis del Peso, Ricardo Sánchez Prieto
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 6, Pp 649-659 (2013)
Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded thro
Externí odkaz: https://doaj.org/article/7634b3ce804f4400989cd66c790679e9
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4
P38 MAPK and Radiotherapy: Foes or Friends?
Autor: Natalia García-Flores, Jaime Jiménez-Suárez, Cristina Garnés-García, Diego M. Fernández-Aroca, Sebastia Sabater, Ignacio Andrés, Antonio Fernández-Aramburo, María José Ruiz-Hidalgo, Borja Belandia, Ricardo Sanchez-Prieto, Francisco J. Cimas
Publikováno v: Cancers. 15:861
Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways affected by IR, p38 MAPK has been shown to be activated both in vitro and in vivo, with involvemen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10abc81cd438cd2775ba88b8293dd490
https://doi.org/10.3390/cancers15030861
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5
Blockage of autophagic flux is associated with lymphocytosis and higher percentage of tumoral cells in chronic lymphocytic leukemia of B cells
Autor: Francisco Ruiz-Marcos, Patricia González-Aguado, Borja Belandia, Olga Roche, Ana Serrano-Martínez, Juan-Ramón Romero-Macías, Ricardo Sánchez-Prieto, Raquel Pascual-Serra, María José Ruiz-Hidalgo
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
[Purpose]: Autophagy has lately emerged as an important biological process with implications in several hematological pathologies. Recently, a growing body of evidence supports a putative role of autophagy in chronic lymphocytic leukemia; however, no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ce358040c4886c8d4eb21b592af877
https://doi.org/10.1007/s12094-019-02041-x
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6
ERK5 signalling pathway is a novel target of sorafenib: Implication in EGF biology
Autor: Raquel Pascual-Serra, Diego M. Fernández-Aroca, Elena Arconada-Luque, Marta Ortega-Muelas, Ismael Muñoz, Ricardo Sánchez-Prieto, Borja Belandia, Olga Roche, Isabel Sánchez-Pérez, María José Ruiz-Hidalgo, José Antonio Encinar, David Albandea‐Rodríguez
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Cellular and Molecular Medicine
© 2021 The Authors.
Sorafenib is a multikinase inhibitor widely used in cancer therapy with an antitumour effect related to biological processes as proliferation, migration or invasion, among others. Initially designed as a Raf inhibitor, Soraf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e75248a9af458ee13eae2f9c9c29e7a
http://hdl.handle.net/10261/265002
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7
P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy
Autor: Olga Roche, Ricardo Sánchez-Prieto, Sebastià Sabater, María José Ruiz-Hidalgo, Raquel Pascual-Serra, Marta Ortega-Muelas, Diego M. Fernández-Aroca, Borja Belandia, I. Sánchez Pérez
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Targeting cell cycle has become one of the major challenges in cancer therapy, being Palbociclib, a CDK4/6 inhibitor, an excellent example. Recently, it has been reported that Palbociclib could be a novel radiosensitizer agent. In an attempt to clari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899d0cb962250883724f993dcf163b5a
http://hdl.handle.net/10261/188896
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8
The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling
Autor: Victoriano Baladrón, Laura López-Sanz, José J. García-Ramírez, María José Ruiz-Hidalgo, Jorge Laborda, Susana López-López, Eva M. Monsalve, Ángela Ballesteros, Almudena Ruiz-García, María José Díaz-Guerra
Publikováno v: The Journal of Immunology. 197:3371-3381
The involvement of NOTCH signaling in macrophage activation by Toll receptors has been clearly established, but the factors and pathways controlling NOTCH signaling during this process have not been completely delineated yet. We have characterized th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97567cb710e75f67d109ecdbe4e29c8
https://doi.org/10.4049/jimmunol.1600421
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9
Reduced salivary gland size and increased presence of epithelial progenitor cells in DLK1-deficient mice
Autor: José J. García-Ramírez, Patricia García-Gallastegui, J Laborda, Maitane Aurrekoetxea, Victoriano Baladrón, María José Ruiz-Hidalgo, Jon Luzuriaga, Fernando Unda, Gaskon Ibarretxe
Publikováno v: Cell and Tissue Research. 364:513-525
DLK1 (PREF1, pG2, or FA1) is a transmembrane and secreted protein containing epidermal growth factor-like repeats. Dlk1 expression is abundant in many tissues during embryonic and fetal development and is believed to play an important role in the reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c1acd1ee7f6b8b1f8e6d5fa6adaed9
https://doi.org/10.1007/s00441-015-2344-z
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10
p38β and Cancer: The Beginning of the Road
Autor: Ricardo Sánchez-Prieto, Olga Roche, Elena Arconada-Luque, María José Ruiz-Hidalgo, Liliana F Mellor, Diego M. Fernández-Aroca, Natalia García-Flores
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7524, p 7524 (2020)
© 2020 by the authors.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is implicated in cancer biology and has been widely studied over the past two decades as a potential therapeutic target. Most of the biological and patholo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3353dea0f082a93e69aa5612ec90872f
https://doi.org/10.3390/ijms21207524
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