Zobrazeno 1 - 9
of 9
pro vyhledávání: '"María José Castellanos-Montiel"'
Autor:
Sarah Lépine, Angela Nauleau-Javaudin, Eric Deneault, Carol X.-Q. Chen, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel, Gilles Maussion, Mathilde Chaineau, Thomas Martin Durcan
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109166- (2024)
Summary: Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS). Furthermore, while mutations in TARDBP (encoding TDP-43) have been
Externí odkaz:
https://doaj.org/article/73868775f5204b04ac9ef6e7679b31de
Autor:
Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid-Pellitero, Irina Shlaifer, María José Castellanos-Montiel, Ziqi Yu, Dulce Valeria Carrillo Valenzuela, María Lacalle-Aurioles, Anita Kriz, Yihong Ye, Thomas M. Durcan, Simon S. Wing
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the misfolding-associated protein secretion (MAPS) pathway. Since th
Externí odkaz:
https://doaj.org/article/976adaa7653347f3b014022aafcd2739
Autor:
María José Castellanos-Montiel, Mathilde Chaineau, Anna Kristyna Franco-Flores, Ghazal Haghi, Dulce Carrillo-Valenzuela, Wolfgang E. Reintsch, Carol X.-Q. Chen, Thomas M. Durcan
Publikováno v:
Cells, Vol 12, Iss 4, p 545 (2023)
A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) have been developed to investigate the underlying causes of selective MN degeneration in motor neuron diseases (MNDs). For instance, spheroids ar
Externí odkaz:
https://doaj.org/article/48f8b568f51d45ba8bb43505c6c1dc6d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been linked to both familial (fALS) and sporadic (sALS) cases of ALS. Among
Externí odkaz:
https://doaj.org/article/1b18372c782941dcb4c1e9bbf782b732
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a p
Externí odkaz:
https://doaj.org/article/cfd93d1ea9ce4c468b6fc0e1048617e7
Autor:
Sarah Lépine, Angela Nauleau-Javaudin, Eric Deneault, Carol X.-Q. Chen, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel, Gilles Maussion, Mathilde Chaineau, Thomas M. Durcan
SummaryCytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS). Furthermore, while mutations in theTARDBPgene (encoding TDP-43) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc157e7897bbef83e921e221bea7f0c
https://doi.org/10.1101/2023.03.22.533562
https://doi.org/10.1101/2023.03.22.533562
Autor:
María José Castellanos-Montiel, Mathilde Chaineau, Anna Kristyna Franco-Flores, Ghazal Haghi, Dulce Carrillo-Valenzuela, Wolfgang E. Reintsch, Carol X.-Q. Chen, Thomas M. Durcan
Motor neuron diseases (MNDs) are characterized by the progressive degeneration of motor neurons (MNs) from the cortex, brainstem and/or the spinal cord. In an effort to understand the underlying causes of this selective degeneration, a multitude ofin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73463a347b63974a5cbc925d65b9fa11
https://doi.org/10.1101/2022.09.22.509079
https://doi.org/10.1101/2022.09.22.509079
Modeling the neuromuscular junction in vitro : an approach to study neuromuscular junction disorders
Publikováno v:
Annals of the New York Academy of Sciences. 1488:3-15
The neuromuscular junction (NMJ) is a specialized structure that works as an interface to translate the action potential of the presynaptic motor neuron (MN) in the contraction of the postsynaptic myofiber. The design of appropriate experimental mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6961d45f6704622fb34a811ab4f7e43
https://doi.org/10.1111/nyas.14504
https://doi.org/10.1111/nyas.14504
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-24 (2022)
Abstract Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43, which are detected in nearly all patients. Mutations in the gene t
Externí odkaz:
https://doaj.org/article/296d3560e94946f1abcb4b4054464963