Zobrazeno 1 - 10
of 73
pro vyhledávání: '"María Jesús Oset Gasque"'
Autor:
Miguel Lobete, Tamel Salinas, Sara Izquierdo-Bermejo, Silvia Socas, María Jesús Oset-Gasque, M. Dolores Martín-de-Saavedra
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Ectodomain shedding (ES) is a fundamental process involving the proteolytic cleavage of membrane-bound proteins, leading to the release of soluble extracellular fragments (shed ectodomains) with potential paracrine and autocrine signaling functions.
Externí odkaz:
https://doaj.org/article/42b2f362fb9047e1b852c77441fb7b17
Autor:
Sara Izquierdo-Bermejo, Beatriz Chamorro, María Dolores Martín-de-Saavedra, Miguel Lobete, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 946 (2024)
Stroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy. Recent interest has focused o
Externí odkaz:
https://doaj.org/article/d9478485d231404bbf591287465f9ff5
Autor:
Ricardo Martín, Alberto Samuel Suárez-Pinilla, Nuria García-Font, M. Luisa Laguna-Luque, Juan C. López-Ramos, María Jesús Oset-Gasque, Agnes Gruart, José M. Delgado-García, Magdalena Torres, José Sánchez-Prieto
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background Fragile X syndrome (FXS), the most common inherited intellectual disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein (FMRP). FMRP is an RNA-binding protein that negatively regulates the exp
Externí odkaz:
https://doaj.org/article/ff4f9de879ab41df9400b25c8afd1be7
Autor:
Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou-Litina, Mourad Chioua, Francisco López-Muñoz, José Marco-Contelles, Ricardo Martínez-Murillo, María Jesús Oset-Gasque
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involve
Externí odkaz:
https://doaj.org/article/cfd84adb79f24477b7bc1bf3cf4176f0
Autor:
Irene Pachón-Angona, Paul J. Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María-Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 121 (2024)
This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds 4a–l, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxida
Externí odkaz:
https://doaj.org/article/91b84aaa929141c3b798a1c55836bddf
Autor:
Beatriz Chamorro, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1364 (2023)
Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy. The abundance of information available on the molecular pathophysiology of
Externí odkaz:
https://doaj.org/article/7e23be5927b04988ba2eb609c819c3c5
Autor:
Isabel Varela-Nieto, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, María Jesús Oset-Gasque, José Marco-Contelles
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing
Externí odkaz:
https://doaj.org/article/c4396688f88040e4bf5810aabd9e2200
Autor:
Dorota G. Piotrowska, Laura Mediavilla, Leticia Cuarental, Iwona E. Głowacka, José Marco-Contelles, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, María Jesús Oset-Gasque
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 8581-8587 (2019)
Externí odkaz:
https://doaj.org/article/600d6d1c337f48cf9ef9471ab8a67cdf
Autor:
Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small
Externí odkaz:
https://doaj.org/article/0bac54c2f9864ac794fb57250198766b
Autor:
Beatriz Chamorro, David García-Vieira, Daniel Diez-Iriepa, Estíbaliz Garagarza, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Molecules, Vol 26, Iss 4, p 1127 (2021)
Herein, we report the neuroprotective and antioxidant activity of 1,1′-biphenyl nitrones (BPNs) 1–5 as α-phenyl-N-tert-butylnitrone analogues prepared from commercially available [1,1′-biphenyl]-4-carbaldehyde and [1,1′-biphenyl]-4,4′-dica
Externí odkaz:
https://doaj.org/article/da359c76ff77491a9ccd5da315b32911