Modulating Protein–Protein Interactions by Cyclic and Macrocyclic Peptides. Prominent Strategies and Examples

Autor: Rosario González-Muñiz, María Ángeles Bonache, María Jesús Pérez de Vega

Publikováno v: Molecules, Vol 26, Iss 2, p 445 (2021)

Cyclic and macrocyclic peptides constitute advanced molecules for modulating protein–protein interactions (PPIs). Although still peptide derivatives, they are metabolically more stable than linear counterparts, and should have a lower degree of fle

Externí odkaz: https://doaj.org/article/40f6c95bd77f4877a0fd4599b3bf9d1e

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

Autor: María Jesús Pérez de Vega, Silvia Moreno-Fernández, Gloria María Pontes-Quero, María González-Amor, Blanca Vázquez-Lasa, Beatriz Sabater-Muñoz, Ana M. Briones, María R. Aguilar, Marta Miguel, Rosario González-Muñiz

Publikováno v: Antioxidants, Vol 9, Iss 9, p 787 (2020)

Antioxidant compounds, including polyphenols, have therapeutic effects because of their anti-inflammatory, antihypertensive, antithrombotic and antiproliferative properties. They play important roles in protecting the cardiovascular and neurological

Externí odkaz: https://doaj.org/article/6a1a989cc2114d189890facbd7df15ba

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators

Autor: Manuel Criado, Francisco Sala, Rosario González-Muñiz, Salvador Sala, María Jesús Pérez de Vega, José Mulet, Marta Ximenis

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 973, p 973 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Volume 22
Issue 2

The &alpha
7 nicotinic acetylcholine receptor (&alpha
7 nAChR) is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain, and inflammation. Allosteric modulation of this receptor might be advantageous to red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7cee67b17255b8c0bd9bfcd80500da
https://www.mdpi.com/1422-0067/22/2/973

1-(2′,5′-dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A positive allosteric modulator of α7 nicotinic receptors with analgesic and neuroprotective activity

Autor: Marta Miguel, Salvador Sala, Manuel Criado, Asia Fernández-Carvajal, María Jesús Pérez de Vega, Antonio Ferrer-Montiel, José Mullet, Francisco Sala, Rosario González-Muñiz, Roberto de la Torre Martínez, Manuela G. López, Cristina Fernández-Mendívil, Silvia Moreno-Fernández, Sara González-Rodríguez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Acetylcholine α7 nicotinic receptors are widely expressed in the brain, where they are involved in the central processing of pain as well as in neuropsychiatric, neurodegenerative, and inflammatory processes. Positive allosteric modulators (PAMs) sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f8169dc1d39b628c11278da45ea156
http://hdl.handle.net/10261/201363

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties

Autor: Rosario González-Muñiz, José Mulet, Roberto de la Torre-Martínez, Salvador Sala, María Jesús Pérez de Vega, Marta Miguel, Antonio Ferrer-Montiel, Silvia Moreno-Fernández, Beatriz Balsera, Asia Fernández-Carvajal, Francisco Sala, Manuel Criado

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Nicotine acethylcholine receptors (nAChRs) play critical roles in cognitive processes, neuroprotection and inflammation. Results: According to their substituents, 1,3-diphenylpropan-1-one derivatives act as α7 nAChRs negative allosteric modulators (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becb7e813bf0cb1303b6300e6915b5b1
https://pubmed.ncbi.nlm.nih.gov/27161515