Zobrazeno 1 - 10 of 18 pro vyhledávání: '"María J Andrés-Manzano"'
1
Akademický článek
Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
Autor: Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-13 (2019)
Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we de
Externí odkaz: https://doaj.org/article/90fa5e8960124fb793cbbc7fdd07bf46
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2
Akademický článek
miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.
Autor: Alberto Del Monte, Ana B Arroyo, María J Andrés-Manzano, Nuria García-Barberá, María S Caleprico, Vicente Vicente, Vanessa Roldán, Rocío González-Conejero, Constantino Martínez, Vicente Andrés
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198932 (2018)
BACKGROUND:Atherosclerosis involves activation of the IRAK1/TRAF6/NF-κB inflammatory cascade, which is negatively regulated by miR146a. Previous studies showed that the TT genotype of rs2431697, located near the miR-146a gene, drives lower miR-146a
Externí odkaz: https://doaj.org/article/dc2a94d4793f46c0b129fd337ec7a1c5
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3
Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction
Autor: Andrés, Alberto Del Monte-Monge, Íñigo Ruiz-Polo de Lara, Pilar Gonzalo, Carla Espinós-Estévez, María González-Amor, Miguel de la Fuente-Pérez, María J. Andrés-Manzano, Víctor Fanjul, Juan R. Gimeno, Roberto Barriales-Villa, Beatriz Dorado, Vicente
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11172
Mutations in the LMNA gene (encoding lamin A/C proteins) cause several human cardiac diseases, including dilated cardiomyopathies (LMNA-DCM). The main clinical risks in LMNA-DCM patients are sudden cardiac death and progressive left ventricular eject
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::042a36457b82d3a0da3e675c1defca05
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5
Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice
Autor: Christian Weber, María J. Andrés-Manzano, Ziad Mallat, Leonor Kremer, Virginia Zorita, Julio Gutiérrez, José María González-Granado, Carlos Silvestre-Roig, Yafa Naim Abu Nabah, Hafid Ait-Oufella, Vicente Andrés, Marian Vila-Caballer, Alberto del Monte-Monge, Pedro Molina-Sánchez, María José Sanz
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The CC chemokine 1 (CCL1, also called I-309 or TCA3) is a potent chemoattractant for leukocytes that plays an important role in inflammatory processes and diseases through binding to its receptor CCR8. Here, we investigated the role of the CCL1-CCR8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46542620c726cbd327f61d6600fb0b1e
https://doi.org/10.1016/j.yjmcc.2019.05.009
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6
Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome
Autor: Yaazan Blanco, María J. Andrés-Manzano, José Jalife, Víctor Fanjul, Pilar Gonzalo, David Filgueiras-Rama, Andre Monteiro da Rocha, Vicente Andrés, J Jaime Díaz-Larrosa, Cristina González-Gómez, Alvaro Macias, Andrew Allan, Daniela Ponce-Balbuena
Publikováno v: Cardiovascular Research
Aims Hutchinson–Gilford progeria syndrome (HGPS) is an ultrarare laminopathy caused by expression of progerin, a lamin A variant, also present at low levels in non-HGPS individuals. HGPS patients age and die prematurely, predominantly from cardiova
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f24170b70fb89a7a0130672f81004c0
https://pubmed.ncbi.nlm.nih.gov/33624748
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7
Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment
Autor: Amanda Sánchez-López, Beatriz Dorado, María J. Andrés-Manzano, Vicente Andrés, Lara del Campo, Cristina González-Gómez
Publikováno v: Cells, Vol 9, Iss 3, p 656 (2020)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cells
Volume 9
Issue 3
Cardiovascular disease (CVD) is the main cause of death worldwide, and aging is its leading risk factor. Aging is much accelerated in Hutchinson&ndash
Gilford progeria syndrome (HGPS), an ultra-rare genetic disorder provoked by the ubiquitous ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad77730e0d6d359e025adf085122260
https://www.mdpi.com/2073-4409/9/3/656
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8
Identification of common cardiometabolic alterations and deregulated pathways in mouse and pig models of aging
Autor: Jesús Vázquez, Vicente Andrés, José Rivera-Torres, Beatriz Dorado, Cristina González-Gómez, Inmaculada Jorge, Ana Barettino, Alvaro Macias, Emilio Camafeita, María J. Andrés-Manzano, Carlos López-Otín, Víctor Fanjul
Publikováno v: RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Repisalud
Instituto de Salud Carlos III (ISCIII)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Aging Cell
Aging is the main risk factor for cardiovascular and metabolic diseases, which have become a global concern as the world population ages. These diseases and the aging process are exacerbated in Hutchinson–Gilford progeria syndrome (HGPS or progeria
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50b4d1c300dd6743871c47c547e973e
http://hdl.handle.net/10651/56245
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9
Premature vascular aging with features of plaque vulnerability in an atheroprone mouse model of Hutchinson-Gilford progeria syndrome with Ldlr deficiency
Autor: Pilar Gonzalo, Rosa M Nevado, María J. Andrés-Manzano, Vicente Andrés, Magda R. Hamczyk
Publikováno v: Scopus
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cells, Vol 9, Iss 2252, p 2252 (2020)
Cells
Volume 9
Issue 10
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Hutchinson&ndash
Gilford progeria syndrome (HGPS) is among the most devastating of the laminopathies, rare genetic diseases caused by mutations in genes encoding nuclear lamina proteins. HGPS patients age prematurely and die in adolescence, typi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8fa17bd3780855690b3b91b0762808
http://hdl.handle.net/10651/58813
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10
Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
Autor: Tom Misteli, Rosa M Nevado, Magda R. Hamczyk, Pilar Gonzalo, Vicente Andrés, Víctor Quesada, Sandra Vidak, María J. Andrés-Manzano, Carlos López-Otín, Ricardo Villa-Bellosta
Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 4, Pp n/a-n/a (2019)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
EMBO Molecular Medicine
Repisalud
Instituto de Salud Carlos III (ISCIII)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd71f28d200c0b13cd11c2411fee9c4
https://doaj.org/article/90fa5e8960124fb793cbbc7fdd07bf46
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