Zobrazeno 1 - 3
of 3
pro vyhledávání: '"María Inés Morano"'
Autor:
Kramer James Bernard, M.C. Holt, Stephen Douglas Barrett, Chi S. Ho, James Paul O'malley, Thomas A. Owen, Adam Uzieblo, Fred L. Ciske, A.J. Stein, Joseph Michael Colombo, María Inés Morano, Bradlee David Germain, Andrei M. Kornilov
Publikováno v:
Journal of Medicinal Chemistry. 62:4731-4741
A series of small-molecule full agonists of the prostaglandin E2 type 4 (EP4) receptor have been generated and evaluated for binding affinity and cellular potency. KMN-80 and its gem-difluoro analog KMN-159 possess high selectivity relative to other
Autor:
Thomas A, Owen, Chandni, Patel, Shanqiao, Wei, Chi S, Ho, Kaylah, Birmingham, Samuel, Sanchez, Natalie, Chung, Alexa, Cahill, James P, O'Malley, Stephen D, Barrett, María Inés, Morano
Publikováno v:
Gene
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP(4) receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP(4) activation. KMN-159 is a potent, selective small m
Autor:
Stephen Douglas Barrett, Kaylah Birmingham, Alexa Cahill, Chandni Patel, James Paul O'malley, Shanqiao Wei, Samuel Sanchez, Thomas A. Owen, María Inés Morano, Natalie Chung, Chi S. Ho
Publikováno v:
Gene. 748:144668
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP4 receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP4 activation. KMN-159 is a potent, selective small molec