Zobrazeno 1 - 10
of 30
pro vyhledávání: '"María I Loza"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209804 (2019)
The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series, accompanied by numerous research articles. Although N-benzyl substitution of 5-methoxytrypt
Externí odkaz:
https://doaj.org/article/9f4bcf336efd4288842c963454b21e34
Autor:
Rubén Prieto-Díaz, Hugo Fojo-Carballo, Maria Majellaro, Tana Tandarić, Jhonny Azuaje, José Brea, María I. Loza, Jorge Barbazán, Glòria Salort, Meera Chotalia, Iván Rodríguez-Pampín, Ana Mallo-Abreu, M. Rita Paleo, Xerardo García-Mera, Francisco Ciruela, Hugo Gutiérrez-de-Terán, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116345- (2024)
Antagonists of the A2B adenosine receptor have recently emerged as targeted anticancer agents and immune checkpoint inhibitors within the realm of cancer immunotherapy. This study presents a comprehensive evaluation of novel Biginelli-assembled pyrim
Externí odkaz:
https://doaj.org/article/49588aec46c84378975a623bef5f1ed4
Autor:
Rubén Prieto-Díaz, Manuel González-Gómez, Hugo Fojo-Carballo, Jhonny Azuaje, Abdelaziz El Maatougui, Maria Majellaro, María I. Loza, José Brea, Víctor Fernández-Dueñas, M. Rita Paleo, Alejandro Díaz-Holguín, Beatriz Garcia-Pinel, Ana Mallo-Abreu, Juan C. Estévez, Antonio Andújar-Arias, Xerardo García-Mera, Iria Gomez-Tourino, Francisco Ciruela, Cristian O. Salas, Hugo Gutiérrez-de-Terán, Eddy Sotelo
Publikováno v:
Journal of Medicinal Chemistry. 66:890-912
Autor:
Javier, García-Cárceles, Henar, Vázquez-Villa, José, Brea, David, Ladron de Guevara-Miranda, Giovanni, Cincilla, Melchor, Sánchez-Martínez, Anabel, Sánchez-Merino, Sergio, Algar, María, Teresa de Los Frailes, Richard S, Roberts, Juan A, Ballesteros, Fernando, Rodríguez de Fonseca, Bellinda, Benhamú, María I, Loza, María L, López-Rodríguez
Publikováno v:
Journal of medicinal chemistry. 65(18)
Tolerance development caused by dopamine replacement with l-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson's disease. In
Autor:
Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de los Frailes, Richard S. Roberts, Juan A. Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I. Loza, María L. López-Rodríguez
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
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Tolerance development caused by dopamine replacement with L-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson’s disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ee8cb90d20910f36acb8e932c24b4d
https://hdl.handle.net/10668/22592
https://hdl.handle.net/10668/22592
Autor:
Maria J. Matos, Paula Novo, Lucía Mayán, Iria Torres, Eugenio Uriarte, Matilde Yáñez, José Ángel Fontenla, Francesco Ortuso, Stefano Alcaro, Francesca Procopio, María Isabel Rodríguez-Franco, Cristina Val, María I. Loza, José Brea, Fernanda Borges, Dolores Viña
Publikováno v:
European Journal of Medicinal Chemistry. 248:115091
Psychiatric and neurological disorders affect millions of people worldwide. Currently available treatments may help to improve symptoms, but they cannot cure the diseases. Therefore, there is an urgent need for potent and safe therapeutic solutions.
Autor:
Juan M. Decara, Henar Vázquez-Villa, José Brea, Mónica Alonso, Raj Kamal Srivastava, Laura Orio, Francisco Alén, Juan Suárez, Elena Baixeras, Javier García-Cárceles, Andrea Escobar-Peña, Beat Lutz, Ramón Rodríguez, Eva Codesido, F. Javier Garcia-Ladona, Teresa A. Bennett, Juan A. Ballesteros, Jacobo Cruces, María I. Loza, Bellinda Benhamú, Fernando Rodríguez de Fonseca, María L. López-Rodríguez
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
instname
Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5204408a5bdfa2a01441f9d69a50b6ec
https://hdl.handle.net/10668/22590
https://hdl.handle.net/10668/22590
Autor:
Luis A. Morán, Ying Di, Marcin A. Sowa, Lidia Hermida-Nogueira, María N. Barrachina, Eleyna Martin, Joanne C. Clark, Todd H. Mize, Johannes A. Eble, David Moreira, Alice Y. Pollitt, María I. Loza, Eduardo Domínguez, Steve P. Watson, Ángel García
Publikováno v:
Thrombosis and Haemostasis
Background CLEC-2 is a platelet receptor with an important role in thromboinflammation but a minor role in hemostasis. Two endogenous ligands of CLEC-2 have been identified, the transmembrane protein podoplanin and iron-containing porphyrin hemin, wh
Autor:
Johanna Andrea Martínez-Villa, Leslie Cayola, Agustina Malizia, Esteban Pinto, Miguel A. Peña, Ricardo Grau, Julieta Carilla, Oriana Osinaga-Acosta, Manuel Peralvo, Jonathan Myers, Marco Calderón-Loor, Peter G. Kennedy, William Farfan-Rios, J. Sebastián Tello, Oliver L. Phillips, Sebastián González-Caro, María I. Loza-Rivera, Alvaro Duque, Yadvinder Malhi, Lucio R. Malizia, Jürgen Homeier, Kenneth J. Feeley, Sassan Saatchi, Alfredo F. Fuentes, Andrea Terán-Valdez, Francisco Cuesta, Cecilia Blundo, Miles R. Silman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29e7cca43fdf7c0389020f0b6c94c99
https://eprints.whiterose.ac.uk/177160/6/s41467-021-23955-7.pdf
https://eprints.whiterose.ac.uk/177160/6/s41467-021-23955-7.pdf
Autor:
Uxía Nogueira-Recalde, Irene Lorenzo-Gómez, Francisco J. Blanco, María I. Loza, Diego Grassi, Valery Shirinsky, Ivan Shirinsky, Martin Lotz, Paul D. Robbins, Eduardo Domínguez, Beatriz Caramés
Publikováno v:
EBioMedicine, Vol 45, Iss, Pp 588-605 (2019)
Background: Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by r