Zobrazeno 1 - 10
of 36
pro vyhledávání: '"María I, Crespo"'
Autor:
Ana L. Chiodetti, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Santiago D. Palma, María C. Pistoresi-Palencia, Gabriel Morón, Belkys A. Maletto
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim, we formulated class-B synthetic oligodeoxynucleotide containing
Externí odkaz:
https://doaj.org/article/e4646cca80bf48179c402199a891433b
Autor:
Estefanía R Zacca, María I Crespo, Rachel P Acland, Emiliano Roselli, Nicolás G Núñez, Mariana Maccioni, Belkys A Maletto, María C Pistoresi-Palencia, Gabriel Morón
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140672 (2015)
The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting cells that play a key role in both adaptive and innate immunity, but how aging affects DCs and thei
Externí odkaz:
https://doaj.org/article/0ddcb9694d7641a68e037090b50f94a6
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24108 (2011)
Baculoviruses (BV) are DNA viruses that are pathogenic for insects. Although BV infect a range of mammalian cell types, they do not replicate in these cells. Indeed, the potential effects of these insect viruses on the immune responses of mammals are
Externí odkaz:
https://doaj.org/article/eb91555c15d94c3eb69c23a69048a9f0
Autor:
María I. Crespo, Héctor Tamashiro, Alicia Lavanchy, María Silvia Di Genaro, Rodolfo Pardo-Hildalgo, Mabel Noemí Dave, Carolina V Gorlino, María C. Pistoresi-Palencia, Rodrigo Blas
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated peptide antibodies (ACPAs) and neutrophils infiltrating the synovial fluid (SF) of the affected joints. The aim of this work was to analyze whether the presence of ACPAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786a6f6d087d382dc055fb195485ce57
Wiley Online Library
Wiley Online Library
Autor:
Carolina V. Gorlino, María I. Crespo, Romina P. Ranocchia, María C. Pistoresi-Palencia, Gabriel Morón, Belkys A. Maletto, María F. Harman, Sofía D. Castell, María F. Sánchez Vallecillo
Publikováno v:
Oncotarget
As we age, the homeostatic function of many systems in the body, such as the immune function declines, which in turn contributes to augment susceptibility to disease. Here we describe that challenging aged mice with synthetic oligodeoxynucleotides co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c2829588527ad1c7a40502326fae2
http://europepmc.org/articles/PMC4537026
http://europepmc.org/articles/PMC4537026
Autor:
Gabriel Morón, Belkys A. Maletto, Carolina V. Gorlino, María I. Crespo, María F. Harman, Romina P. Ranocchia, Iris Alejandra García, María C. Pistoresi-Palencia
Publikováno v:
The Journal of Immunology. 193:1966-1974
Although much is described about the molecules involved in neutrophil migration from circulation into tissues, less is known about the molecular mechanisms that regulate neutrophil entry into lymph nodes (LNs) draining a local inflammatory site. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7370ec0318706c3081d31d608842ff
https://doi.org/10.4049/jimmunol.1301791
https://doi.org/10.4049/jimmunol.1301791
IFNβ Produced by TLR4-Activated Tumor Cells Is Involved in Improving the Antitumoral Immune Response
Autor:
Virginia Andreani, Lien Dejager, Gabriel Morón, Maria Laura Breser, Virginia Elena Rivero, David Andrés Nocera, María I. Crespo, Nicolás Gonzalo Núñez, Mariana Maccioni, Claude Libert
Publikováno v:
Cancer Research. 72:592-603
Toll-like receptor (TLR) ligands may be a valuable tool to promote antitumor responses by reinforcing antitumor immunity. In addition to their expression in immune cells, functional TLRs are also expressed by many cancer cells, but their significance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5359afcfb0658c45819794c9c22d3a3
https://doi.org/10.1158/0008-5472.can-11-0534
https://doi.org/10.1158/0008-5472.can-11-0534
Autor:
Joan Albertí, Manuel Fuentes Ferrer, Sonia Sentellas, María I. Crespo, Hamish Ryder, Amadeu Gavaldà, Jorge Beleta, Israel Ramos, M. Antonia Buil, Sonia Espinosa, Manuel López, Jordi Castro, Maria Prat, Francisca Antón, Josep M. Huerta, Dolors Fernández, Marisa González, Gaspar Casals, Dolors Vilella, Teresa Doménech, Victor Segarra, Montserrat Miralpeix, Alvaro Cardenas, Juan Manuel Monleón, Laia Tort
Publikováno v:
Journal of Medicinal Chemistry. 52:5076-5092
The objective of this work was to discover a novel, long-acting muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD), with a potentially improved risk−benefit profile compared with current antimuscarini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45428bc44e0992b58d50d3c5f07d6aa2
https://doi.org/10.1021/jm900132z
https://doi.org/10.1021/jm900132z
Autor:
Marion Lanier, Xiaohu Zhang, John E. Tellew, Zhiyong Luo, Mark Santos, Raymond S. Gross, Deborah H. Slee, Emily Lin, Sandra M. Lechner, Jaimie K. Rueter, María I. Crespo, Jose-Luis Diaz, Yongsheng Chen, Siobhan Malany, Manisha Moorjani, John Saunders, John P. Williams, Binh G. Vong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5402-5405
In this report, the strategy and outcome of expanding SAR exploration to improve solubility and metabolic stability are discussed. Compound 35 exhibited excellent potency, selectivity over A(1) and improved solubility of >4 mg/mL at pH 8.0. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d40e0876b3b15e810f1648d5b9dc2
https://doi.org/10.1016/j.bmcl.2008.09.048
https://doi.org/10.1016/j.bmcl.2008.09.048
Autor:
Hamish Ryder, Alvaro Cardenas, Jordi Beleta, Nuria Godessart, María I. Crespo, Francisco Caturla, Mercè Amat, Lidia Soca, Juan-Miguel Jiménez
Publikováno v:
Journal of Medicinal Chemistry. 47:3874-3886
A series of 2-phenylpyran-4-ones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56497aad23d8b81b6ddefe8267e43a37
https://doi.org/10.1021/jm049882t
https://doi.org/10.1021/jm049882t