Urinary metabolic phenotyping for Alzheimer’s disease

Autor: Natalja Kurbatova, Manik Garg, Luke Whiley, Elena Chekmeneva, Beatriz Jiménez, María Gómez-Romero, Jake Pearce, Torben Kimhofer, Ellie D’Hondt, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Dag Aarsland, Alejo Nevado-Holgado, Benjamine Liu, Stuart Snowden, Petroula Proitsi, Nicholas J. Ashton, Abdul Hye, Cristina Legido-Quigley, Matthew R. Lewis, Jeremy K. Nicholson, Elaine Holmes, Alvis Brazma, Simon Lovestone

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Abstract Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we repor

Externí odkaz: https://doaj.org/article/1bd85f619d574055ba7c1fb49956bdea

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

Autor: Hanns-Ulrich Marschall, Ann Smith, Fouzia Sadiq, Julian R. Marchesi, Caroline Ovadia, Konstantina Spagou, Alice Mitchell, Elena Bellafante, Natalie Santa‐Pinter, Magali Sarafian, Alvaro Perdones-Montero, Shadi Abu-Hayyeh, Peter H. Dixon, Catherine Williamson, Annika Wahlström, María Gómez-Romero, Louise C. D. Clarke, Vanya Nikolova, Julian R.F. Walters, Elaine Holmes

Publikováno v: Hepatology (Baltimore, Md.)
Ovadia, C, Perdones-Montero, A, Spagou, K, Smith, A, Sarafian, M H, Gomez Romero, M, Bellafante, E, Clarke, L CD, Sadiq, F, Nikolova, V, Mitchell, A, Dixon, P H, Santa-Pinter, N, Wahlström, A, Abu-Hayyeh, S, Walters, J, Marschall, H-U, Holmes, E, Marchesi, J R & Williamson, C 2019, ' Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis ', Hepatology, vol. 70, no. 1, pp. 276-293 . https://doi.org/10.1002/hep.30661

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a4faa1f362ea02136252cd02e7421e
http://europepmc.org/articles/PMC6619257

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis

Autor: Joram M. Posma, Matthew R. Lewis, Robindra Basu Roy, Leopold D. Tientcheu, Uzochukwu Egere, María Gómez-Romero, Elaine Holmes, Nicholas J. Andreas, Beate Kampmann, Toyin Togun, Verena Horneffer-van der Sluis, Stephane Camuzeaux, Abdou K. Sillah, Beatriz Jiménez

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

We applied a metabonomic strategy to identify host biomarkers in serum to diagnose paediatric tuberculosis (TB) disease. 112 symptomatic children with presumptive TB were recruited in The Gambia and classified as bacteriologically-confirmed TB, clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c09751fd6436b5032b81c7217a74d89
http://hdl.handle.net/10044/1/84093

Characterisation of phenolic compounds in Algerian honeys by RP-HPLC coupled to electrospray time-of-flight mass spectrometry

Autor: Farid Aboud, Alberto Fernández-Gutiérrez, Alonzo Giuseppe, Antonio Segura-Carretero, Nadia Amessis-Ouchemoukh, Salim Ouchemoukh, María Gómez-Romero

Publikováno v: LWT - Food Science and Technology. 85:460-469

A total of 35 honey samples from different regions of Algeria were studied to determine their phenolic profiles. Phenolic compounds, products of the secondary metabolism of plants, were extracted with amberlite XAD-4 and analysed by liquid chromatogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7b69ba58b1c60438461f8c238cbdb78
https://doi.org/10.1016/j.lwt.2016.11.084

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

Autor: James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross

Publikováno v: Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)

Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Method

Externí odkaz: https://doaj.org/article/12e07005f08c4eff961ce1c2bc1eb63e