Zobrazeno 1 - 10
of 16
pro vyhledávání: '"María Florencia, Pignataro"'
Autor:
Natalia Brenda Fernández, María Georgina Herrera, Matías Blaustein, María Florencia Pignataro
Publikováno v:
Frontiers in Medicine, Vol 10 (2024)
Externí odkaz:
https://doaj.org/article/2d5128de074941dbba0458142cf1dc82
Autor:
María Lorena Bacigalupo, María Florencia Pignataro, Carolinne Thays Scopel, Sergiy Kondratyuk, Othoman Mellouk, Gabriela Costa Chaves
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
In the pharmaceutical sector, evergreening is considered a range of practices applied to extend monopoly protection on existing products. Filing several patent applications related to the same active pharmaceutical ingredient (API) is one of the most
Externí odkaz:
https://doaj.org/article/3f3cd794795b428598402289becbf8cc
Autor:
María Florencia Pignataro, María Georgina Herrera, Natalia Brenda Fernández, Martín Aran, Hernán Gustavo Gentili, Fernando Battaglini, Javier Santos
Publikováno v:
Biotechnology and Bioengineering. 120:409-425
Frataxin is a kinetic activator of the mitochondrial supercomplex for iron-sulfur cluster assembly. Low frataxin expression or a decrease in its functionality results in Friedreich's Ataxia (FRDA). With the aim of creating new molecular tools to stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3dc0d9342cc45593ac310c1430ed5
https://doi.org/10.1002/bit.28263
https://doi.org/10.1002/bit.28263
Publikováno v:
Molecules, Vol 25, Iss 20, p 4854 (2020)
The self-assembly of proteins is an essential process for a variety of cellular functions including cell respiration, mobility and division. On the other hand, protein or peptide misfolding and aggregation is related to the development of Parkinson
Externí odkaz:
https://doaj.org/article/29fec2c8b9904a7fa2d3bcbbd1feae48
Autor:
Luciana Capece, María Florencia Pignataro, Liliana Dain, Ignacio Hugo Castro, Lucía D. Espeche, Javier Santos, Karl Ellioth Sewell
Publikováno v:
Archives of biochemistry and biophysics. 715
In humans, the loss of frataxin results in Friedreich's Ataxia, a neurodegenerative disease, in which a deficit in the iron-sulfur cluster assembly is observed. In this work, we analyzed three frataxin variants in which one tryptophan was replaced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaa373c497171a4333b85766db68400
https://pubmed.ncbi.nlm.nih.gov/34801473
https://pubmed.ncbi.nlm.nih.gov/34801473
Autor:
Justo, Olmos, María Florencia, Pignataro, Ana Belén, Benítez Dos Santos, Mauro, Bringas, Sebastián, Klinke, Laura, Kamenetzky, Francisco, Velazquez, Javier, Santos
Publikováno v:
International Journal of Molecular Sciences
Several biological activities depend on iron–sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We propose to use the amoeba D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2af9554adf7145dc3cbafe0b31b36309
https://pubmed.ncbi.nlm.nih.gov/32957566
https://pubmed.ncbi.nlm.nih.gov/32957566
Autor:
Ignacio Hugo, Castro, María Florencia, Pignataro, Karl Ellioth, Sewell, Lucía Daniela, Espeche, María Georgina, Herrera, Martín Ezequiel, Noguera, Liliana, Dain, Alejandro Daniel, Nadra, Martín, Aran, Clara, Smal, Mariana, Gallo, Javier, Santos
Publikováno v:
Sub-cellular biochemistry. 93
Mammalian frataxin is a small mitochondrial protein involved in iron sulfur cluster assembly. Frataxin deficiency causes the neurodegenerative disease Friedreich's Ataxia. Valuable knowledge has been gained on the structural dynamics of frataxin, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85301345e3a126ac5360febbfe5a2f72
https://pubmed.ncbi.nlm.nih.gov/31939159
https://pubmed.ncbi.nlm.nih.gov/31939159
Autor:
María V. Espelt, Pablo J. Schwarzbaum, Mariela S. Ferreira-Gomes, José M. Delfino, Carla Romina Angelani, Damiana María Salvatierra Fréchou, Nicolás A. Saffioti, Gabriela E. Gómez, Karen Magalí Cruz, Irene C. Mangialavori, Pablo Carabias, Marilina de Sautu, María Florencia Pignataro, Javier Santos, Malena Manzi
Publikováno v:
Biochemistry and Molecular Biology Education. 46:502-515
Metabolic control analysis (MCA) is a promising approach in biochemistry aimed at understanding processes in a quantitative fashion. Here the contribution of enzymes and transporters to the control of a given pathway flux and metabolite concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36822a4ff5cb219d25a9862d88fa9920
https://doi.org/10.1002/bmb.21139
https://doi.org/10.1002/bmb.21139
Autor:
Ana Belén Benítez Dos Santos, Laura Kamenetzky, Justo Olmos, Francisco Velazquez, María Florencia Pignataro, Sebastián Klinke, Mauro Bringas, Javier Santos
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 18
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Molecular Sciences, Vol 21, Iss 6821, p 6821 (2020)
Volume 21
Issue 18
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Molecular Sciences, Vol 21, Iss 6821, p 6821 (2020)
Several biological activities depend on iron&ndash
sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We propose to use the
sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We propose to use the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e84b5bc2e12122464df236849755f4
https://doi.org/10.3390/ijms21186821
https://doi.org/10.3390/ijms21186821
Autor:
Maria Georgina Herrera, Karen Magalí Cruz, María Florencia Pignataro, Martín Ezequiel Noguera, Javier Santos
Publikováno v:
ACS chemical biology. 13(6)
Iron-sulfur clusters are essential cofactors in many biochemical processes. ISD11, one of the subunits of the protein complex that carries out the cluster assembly in mitochondria, is necessary for cysteine desulfurase NFS1 stability and function. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7a6e82c7d58f163388038cb25b5184
https://pubmed.ncbi.nlm.nih.gov/29737835
https://pubmed.ncbi.nlm.nih.gov/29737835