Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

Autor: Carolina Céspedes-Garro, Gerardo Jiménez-Arce, María-Eugenia G. Naranjo, Ramiro Barrantes, Adrián LLerena

Publikováno v: Revista de Biología Tropical, Vol 62, Iss 4, Pp 1659-1671 (2014)

CYP2D6 differences have already been demonstrated within Latin American populations by the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics (RIBEF, as per the acronym in Spanish). However, within the population of Costa Rica, no

Externí odkaz: https://doaj.org/article/9044287b5f054dc5b5f84a2c8d623cca

Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics

Autor: María-Eugenia G. Naranjo, Fernanda Rodrigues-Soares, Eva M. Peñas-Lledó, Eduardo Tarazona-Santos, Humberto Fariñas, Idania Rodeiro, Enrique Terán, Manuela Grazina, Graciela E. Moya, Marisol López-López, Alba P. Sarmiento, Luis R. Calzadilla, Ronald Ramírez-Roa, Rocío Ortiz-López, Francisco E. Estévez-Carrizo, Martha Sosa-Macías, Ramiro Barrantes, Adrián LLerena, Verónica Fcrreiro, Marilia O. Scliar, Mateus H Gouveia, Angélica Borbón, Gerardo Jiménez-Arce, Carolina Céspedes-Garro, Mayra Álvárez, René Delgado, Diadelis Remirez, Bárbaro Pérez, Francisco Hernández, Santiago Terán, Augusto Rojas-Martinez, Lourdes Garza-Ocañas, Yadira X. Pérez-Páramo, Alberto Ortega-Vázquez, Nancy Monroy-Jaramillo, Helgi Jung-Cook, Ingrid Fricke-Galindo, Carlos Galaviz-Hernández, Ismael Lares-Aseff, Blanca P. Lazalde-Ramos, Catalina Altamirano Tinoco, Roxana Zamudio, Robert H. Gilman, Jesús Cobaleda, Fernando de Andrés, Pedro Dorado, Eugenia G. Naranjo

Publikováno v: OMICS: A Journal of Integrative Biology. 2018, 22(09)
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Fil: Naranjo, María Eugenia G. RIBEF Ibero-American Network of Pharmacogenetics and Pharmacogenomics; España Fil: Naranjo, María Eugenia G. Universidad de Extremadura; España Fil: Rodrigues Soares, Fernanda. RIBEF Ibero-American Network of Pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4841c2aa2c820c941677f0358581e3b4
https://pubmed.ncbi.nlm.nih.gov/30183544

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico

Autor: Idalia Garza-Veloz, Blanca Patricia Lazalde-Ramos, Martha Sosa-Macías, María Eugenia G Naranjo, Margarita L Martinez-Fierro, Adrián LLerena, Carlos Galaviz-Hernández

Publikováno v: Pharmacogenomics. 15:339-348

Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0953ec108f5990fef6f07b7d640ce370
https://doi.org/10.2217/pgs.13.203

Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications

Autor: Carolina Ribeiro, Manuela Grazina, María Eugenia G Naranjo, José Albuquerque, Adrián LLerena

Publikováno v: Personalized Medicine. 10:709-718

Aim:CYP2D6 codes for a protein that is vastly involved in the metabolism of various substances. This gene is highly polymorphic, which influences the enzymatic activity and contributes to the huge variability in the enzyme hydroxylation capacity. Dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84fa9872c1473dfce4cdd3d18165112
https://doi.org/10.2217/pme.13.56

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations

Autor: Eva M Peñas-Lledó, Humberto Fariñas, Adrián LLerena, Fernanda Rodrigues-Soares, María Eugenia G Naranjo, Eduardo Tarazona-Santos

Publikováno v: Expert opinion on drug metabolismtoxicology. 10(11)

The frequency of CYP2D6 alleles, related to either a lack of or increased enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM), can vary across ethnic groups and hence across geographic regions.Worldwide original r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed90e5d207031717272e849c636c7ec1
https://pubmed.ncbi.nlm.nih.gov/25316321