Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages

Autor: Federico Nicolás Penas, Davide Carta, Ágata Carolina Cevey, María Jimena Rada, Azul Victoria Pieralisi, María Grazia Ferlin, María Elena Sales, Gerardo A. Mirkin, Nora Beatriz Goren

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Chagas disease is caused by Trypanosoma cruzi infection and represents an important public health concern in Latin America. Macrophages are one of the main infiltrating leukocytes in response to infection. Parasite persistence could trigger a sustain

Externí odkaz: https://doaj.org/article/c762bd450ddd4e6991ccea302c57b243

Breast cancer: Muscarinic receptors as new targets for tumor therapy

Autor: María Elena Sales, Agustina Reina Salem, Yamila Sanchez, Alejandro Español

Publikováno v: World Journal of Clinical Oncology

The development of breast cancer is a complex process that involves the participation of different factors. Several authors have demonstrated the overexpression of muscarinic acetylcholine receptors (mAChRs) in different tumor tissues and their role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963750c948eed0741b11c45a577e8b1c
https://pubmed.ncbi.nlm.nih.gov/34189066

The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype

Autor: Maria Di Bari, María Elena Sales, Alejandro Javier Español, Yamila Sanchez, Ada Maria Tata, Agustina Reina Salem, Ilaria Cristofaro

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0226450 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019ded12bb446135eddba6779f38ff09
http://europepmc.org/articles/PMC7482849

Benefits of metronomic therapy targeting muscarinic receptors in breast cancer as a sensitizer of cells to classic chemotherapy with paclitaxel

Autor: Francisco Sánchez, Alejandro J. Español, Yamila Sanchez, Agustina R. Salem, María Elena Sales, Paola Martinez Pulido

Publikováno v: Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO1-8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d42cb331d880001b7f0a0973d662776
https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-8-31

Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor

Autor: Claudia Cocca, María Elena Sales, Laura Alvarez, Alejandro Español, Noelia Miret, Andrea Randi, Lorena Vanesa Zárate, Florencia Chiappini, Carolina Pontillo, Diana Kleiman de Pisarev

Publikováno v: Toxicology and Applied Pharmacology. 401:115093

Breast cancer incidence is increasing globally and pesticides exposure may impact risk of developing this disease. Hexachlorobenzene (HCB) and chlorpyrifos (CPF) act as endocrine disruptors, inducing proliferation in breast cancer cells. Vascular end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289d6af246a8fdd0a0d83af1e266d8f8
https://doi.org/10.1016/j.taap.2020.115093