Harmful R-loops are prevented via different cell cycle-specific mechanisms

Autor: Marta San Martin-Alonso, María E. Soler-Oliva, María García-Rubio, Tatiana García-Muse, Andrés Aguilera

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case,

Externí odkaz: https://doaj.org/article/b783d30442df48748c1102cb0f8b0a58

Analysis of the relationship between coexpression domains and chromatin 3D organization

Autor: María E. Soler-Oliva, José C. Reyes, José A. Guerrero-Martínez, Valentina Bachetti

Publikováno v: PLoS Computational Biology
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
PLoS Computational Biology, Vol 13, Iss 9, p e1005708 (2017)
Digital.CSIC. Repositorio Institucional del CSIC

Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that determine co-regulation of large regions of the genome and its connection with chromatin three-dimensional (3D) organization are stil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6171ccf544b50530e18a859f65de9b85
http://europepmc.org/articles/PMC5612749