Nitrosative stress in human spermatozoa causes cell death characterized by induction of mitochondrial permeability transition-driven necrosis

Autor: Pamela Uribe, María E Cabrillana, Miguel W Fornés, Favián Treulen, Rodrigo Boguen, Vladimir Isachenko, Evgenia Isachenko, Raúl Sánchez, Juana V Villegas

Publikováno v: Asian Journal of Andrology, Vol 20, Iss 6, Pp 600-607 (2018)

Peroxynitrite is a highly reactive nitrogen species and a potent inducer of apoptosis and necrosis in somatic cells. Peroxynitrite-induced nitrosative stress has emerged as a major cause of impaired sperm function; however, its ability to trigger cel

Externí odkaz: https://doaj.org/article/b92ca59a5ef9494883cd17dc611715cf

Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model.

Autor: Layla Simón, Abi K Funes, Martín A Yapur, María E Cabrillana, María A Monclus, Paola V Boarelli, Amanda E Vincenti, Tania E Saez Lancellotti, Miguel W Fornés

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172994 (2017)

Hypercholesterolemia is a marker for several adult chronic diseases. Recently we demonstrated that sub/infertility is also associated to Hypercholesterolemia in rabbits. Seminal alterations included: abnormal sperm morphology, decreased sperm number

Externí odkaz: https://doaj.org/article/dbed43ee57174d15a845d91d0e0fb14f

Impact of high fat diet on the sterol regulatory element-binding protein 2 cholesterol pathway in the testicle

Autor: Paola Boarelli, Julieta Crescitelli, Niubys Cayado, A. Funes, L. Simón, Regina Colombo, María Inés Conte, Maria de Los Angeles Monclus, María Virginia Avena, Miguel W. Fornés, Tania E. Saez Lancellotti, María E. Cabrillana

Publikováno v: Molecular Human Reproduction. 27

Male fertility has been shown to be dependent on cholesterol homeostasis. This lipid is essential for testosterone synthesis and spermatogenesis, but its levels must be maintained in an optimal range for proper testicular function. In particular, spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625db34ece5c203307fa51b44b80ea25
https://doi.org/10.1093/molehr/gaab023

Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model

Autor: María E. Cabrillana, Paola Boarelli, Miguel W. Fornés, L. Simón, A. Funes, Tania E. Saez Lancellotti, Amanda E. Vincenti, Martín A. Yapur, Maria de Los Angeles Monclus

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 12, Iss 2, p e0172994 (2017)
PLoS ONE

Hypercholesterolemia is a marker for several adult chronic diseases. Recently we demonstrated that sub/infertility is also associated to Hypercholesterolemia in rabbits. Seminal alterations included: abnormal sperm morphology, decreased sperm number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d05e292b62022980877e463b440e353
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172994

Simultaneous Study of Cholesterol and GM1 Ganglioside by Specific Probes: Lipid Distribution during Maturation, Capacitation and the Acrosome Reaction

Autor: María E. Cabrillana, A. Funes, L. Simón, Paola Boarelli, Miguel W. Fornés, Tania E. Saez Lancellotti, Maria de Los Angeles Monclus

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Lipid distribution has been extensively studied in the plasma membrane of the male gamete due to its relevant role in sperm physiology. However, there are controversial reports about their distribution. Because of different reports about this topic,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c76a78bbc8c1c610e5a20257a58091
https://doi.org/10.4172/2157-7099.1000412