Zobrazeno 1 - 10
of 29
pro vyhledávání: '"María Del Mar Noblejas-López"'
Autor:
María del Mar Noblejas-López, Elena García-Gil, Pedro Pérez-Segura, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Regulatory T cells (Tregs) is a subtype of CD4+ T cells that produce an inhibitory action against effector cells. In the present work we interrogated genomic datasets to explore the transcriptomic profile of breast tumors with high expressio
Externí odkaz:
https://doaj.org/article/74224a059ba148d49dfab9e6ca39f072
Autor:
María del Mar Noblejas-López, David Tébar-García, Raquel López-Rosa, Ana Alcaraz-Sanabria, Pablo Cristóbal-Cueto, Alejandro Pinedo-Serrano, Lorenzo Rivas-García, Eva M. Galán-Moya
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2442 (2023)
Targeted protein degradation has emerged as an alternative therapy against cancer, offering several advantages over traditional inhibitors. The new degrader drugs provide different therapeutic strategies: they could cross the phospholipid bilayer mem
Externí odkaz:
https://doaj.org/article/25899f23c6a746d5995a9daa49ed80ef
Autor:
María del Mar Noblejas-López, Cristina Nieto-Jiménez, Eva M. Galán-Moya, David Tebar-García, Juan Carlos Montero, Atanasio Pandiella, Miguel Burgos, Alberto Ocaña
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-12 (2021)
Abstract Background Although the anti-HER2 antibody trastuzumab augments patient survival in HER2+ breast cancer, a relevant number of patients progress to this treatment. In this context, novel drug combinations are needed to increase its antitumor
Externí odkaz:
https://doaj.org/article/27735656da444e08a86d58977135ef31
Options to Improve the Action of PROTACs in Cancer: Development of Controlled Delivery Nanoparticles
Autor:
Alberto Juan, María del Mar Noblejas-López, María Arenas-Moreira, Carlos Alonso-Moreno, Alberto Ocaña
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Classical targeting in cancer focuses on the development of chemical structures able to bind to protein pockets with enzymatic activity. Some of these molecules are designed to bind the ATP side of the kinase domain avoiding protein activation and th
Externí odkaz:
https://doaj.org/article/94ee7cee8c9445afb5209d2affc63d1e
Autor:
María del Mar Noblejas-López, Cristina Nieto-Jimenez, Miguel Burgos, Mónica Gómez-Juárez, Juan Carlos Montero, Azucena Esparís-Ogando, Atanasio Pandiella, Eva M. Galán-Moya, Alberto Ocaña
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-9 (2019)
Abstract Background Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Proteolysis targeting chimeric (PROTAC) are novel compounds that promote protein degradation by binding to an ubiquitin li
Externí odkaz:
https://doaj.org/article/037decabfb344e37b370504e1a55b383
Autor:
María del Mar Noblejas-López, Lucía Gandullo-Sánchez, Eva M. Galán-Moya, Raquel López-Rosa, David Tébar-García, Cristina Nieto-Jiménez, Mónica Gómez-Juárez, Miguel Burgos, Atanasio Pandiella, Alberto Ocaña
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5476 (2022)
Cyclin-dependent kinases (CDKs) are a broad family of proteins involved in the cell cycle and transcriptional regulation. In this article, we explore the antitumoral activity of a novel proteolysis-targeting chimera (PROTAC) compound against CDK9. Br
Externí odkaz:
https://doaj.org/article/7a179b3875cc48c09e6d42df7b04d5eb
Autor:
María del Mar Noblejas-López, Cristina Nieto-Jiménez, Sara Morcillo García, Javier Pérez-Peña, Miriam Nuncia-Cantarero, Fernando Andrés-Pretel, Eva M. Galán-Moya, Eitan Amir, Atanasio Pandiella, Balázs Győrffy, Alberto Ocana
Publikováno v:
OncoImmunology, Vol 8, Iss 10 (2019)
Antigen recognition by MHC class I molecules is a key step for the initiation of the immune response. We hypothesized that expression of these molecules could be a marker of immune-activated breast cancers. Data from KM Plotter were extracted to deve
Externí odkaz:
https://doaj.org/article/8c2c47d7e46c4a24addd7d85cd563d38
Autor:
María del Mar Noblejas-López, Mariona Baliu-Piqué, Cristina Nieto-Jiménez, Francisco J. Cimas, Esther C. Morafraile, Atanasio Pandiella, Ángel L. Corbi, Balázs Győrffy, Alberto Ocaña
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3836 (2021)
Targeting the innate immune system has attracted attention with the development of anti- CD47 antibodies. Anti-CD47 antibodies block the inhibition of the phagocytic activity of macrophages caused by the up-regulation of CD47 on tumor cells. In this
Externí odkaz:
https://doaj.org/article/2020565bf5d94da6b7bf15647782f3bc
Autor:
Francisco J. Cimas, Enrique Niza, Alberto Juan, María del Mar Noblejas-López, Iván Bravo, Agustín Lara-Sanchez, Carlos Alonso-Moreno, Alberto Ocaña
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 986 (2020)
Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation through the ubiquitination of the tagged to BET inhibitors Bromodomain proteins, BRD2 and BRD
Externí odkaz:
https://doaj.org/article/11103c891af34522ac86b866ec31ff02
Autor:
María Del Mar Noblejas-López, Sara Morcillo-García, Cristina Nieto-Jiménez, Miriam Nuncia-Cantarero, Balázs Győrffy, Eva M Galan-Moya, Atanasio Pandiella, Alberto Ocaña
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207776 (2018)
Regulation of transcription is a key process in cellular homeostasis. It depends on regulators that either repress or stimulate the transcription of genes, therefore controlling different biological functions. The Nuclear Receptor Corepressor 1 (NCOR
Externí odkaz:
https://doaj.org/article/38a077cf344646c396b1fd0ee35e5b34