Výsledky vyhledávání - "María Daniela Ruiz"

Akademický článek

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Autor: Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strateg

Externí odkaz: https://doaj.org/article/bded6618356b4c7abc4fc7387b8c8543

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A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

Autor: María Laura Sbaraglini, Seppo Parkkila, María Daniela Ruiz, Andrea Angeli, Luciana Gavernet, Claudiu T. Supuran, Carolina Carrillo, Manuel A. Llanos, Maria Villalba, Catalina D. Alba Soto, Alan Talevi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 21-30 (2020)

Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e00e9c6d695c64d69f231333b6bad4
https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1677638

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Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

Autor: Juan Francisco Morales, Agustina María Pino Martínez, María Daniela Ruiz, Lucas Nicolás Alberca, Pablo Hernán Palestro, María Laura Sbaraglini, Catalina D. Alba Soto, Roque Carlos Dietrich, Alan Talevi, Laura Virginia Fraccaroli, Carolina Carrillo, Cristian Gabriel Miranda

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular and Infection Microbiology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ca34a9bef8119aedd5953fcd274f49
https://doi.org/10.3389/fcimb.2018.00173

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Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening

Autor: Pablo Hernán Palestro, María Daniela Ruiz, Roque Carlos Dietrich, Luciana Gavernet, Alan Talevi, Carolina Carrillo, Lucas Nicolás Alberca

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Nowadays, the pharmacological therapy for the treatment of Chagas disease is based on two old drugs, benznidazole and nifurtimox, which have restricted efficacy against the chronic phase of the illness. To overcome the lack of efficacy of the traditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae1afe47adbef1d7de490a634271d97
http://sedici.unlp.edu.ar/handle/10915/101758

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