Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization

Autor: Alicia Aliena-Valero, Macarena Hernández-Jiménez, Mikahela A. López-Morales, Eva Tamayo-Torres, María Castelló-Ruiz, David Piñeiro, Marc Ribó, Juan B. Salom

Publikováno v: Pharmaceutics, Vol 16, Iss 6, p 741 (2024)

ApTOLL, a TLR4 modulator aptamer, has demonstrated cerebroprotective effects in a permanent ischemic stroke mouse model, as well as safety and efficacy in early phase clinical trials. We carried out reverse translation research according to STAIR rec

Externí odkaz: https://doaj.org/article/f15b46d9ad1a4a78a88ca35a573a9b02

Role of Antioxidants in Cooled Liquid Storage of Mammal Spermatozoa

Autor: Miguel A. Silvestre, Jesús L. Yániz, Fernando J. Peña, Pilar Santolaria, María Castelló-Ruiz

Publikováno v: Antioxidants, Vol 10, Iss 7, p 1096 (2021)

Cooled preservation of semen is usually associated with artificial insemination and genetic improvement programs in livestock species. Several studies have reported an increase in reactive oxidative species and a decrease in antioxidant substances an

Externí odkaz: https://doaj.org/article/91c4921773bd451f953b5e54a80fdef1

Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis

Autor: Germán Torregrosa, Alicia Aliena-Valero, Juan B. Salom, Júlia Baixauli-Martín, David Hervás, María Castelló-Ruiz

Publikováno v: J Cereb Blood Flow Metab

Addition of uric acid (UA) to thrombolytic therapy, although safe, showed limited efficacy in improving patients’ stroke outcome, despite alleged neuroprotective effects of UA in preclinical research. This systematic review assessed the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf12528f32132cd049f6a3de0376b94
https://doi.org/10.1177/0271678x20967459

Potassium channels contribute to the increased sensitivity of the rabbit carotid artery to hydrogen sulfide in diabetes

Autor: Teresa Jover-Mengual, Alicia Aliena-Valero, María Castelló-Ruiz, Francisco J. Miranda, María C. Burguete, Mikahela A. López-Morales, José M. Centeno

Publikováno v: EUROPEAN JOURNAL OF PHARMACOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Hydrogen sulfide (H2S) is a potential endothelium-derived hyperpolarizing factor (EDHF) and adventitium- or adipocyte-derived relaxing factor (ADRF) which vasorelaxant action is mediated by potassium channels. H2S could also play an important role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386b43c86b44339629a71dc32d4bbf3
https://doi.org/10.1016/j.ejphar.2019.03.019

Insight into the molecular sex dimorphism of ischaemic stroke in rat cerebral cortex: Focus on neuroglobin, sex steroids and autophagy

Autor: Germán Torregrosa, Estefania Acaz-Fonseca, Luis M. Garcia-Segura, Alicia Aliena-Valero, María Castelló-Ruiz, Juan B. Salom, María C. Burguete

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
EUROPEAN JOURNAL OF NEUROSCIENCE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Including sex is of paramount importance in preclinical and clinical stroke researches, and molecular studies dealing in depth with sex differences in stroke pathophysiology are needed. To gain insight into the molecular sex dimorphism of ischaemic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee3b2320533810b18e429476103b5c9
http://hdl.handle.net/10261/220504