Zobrazeno 1 - 10
of 13
pro vyhledávání: '"María Carmen Costas-Lago"'
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 12, Pp o1859-o1860 (2013)
In the title compound, C21H24N2O2Si, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether group are placed toward opposite sides and the tert-butyl and pyridazinone moieties are anti-oriented across the Si—O bond [torsion a
Externí odkaz:
https://doaj.org/article/c6cb4bf8568e440a842c4a9be63f7702
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 12, Pp o1826-o1827 (2013)
In the title compound, C21H24N2O2Si, a new pyridazin-3(2H)-one derivative, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether are located on the same side of the pyridazinone ring and the C—C—O—Si torsion angle is −
Externí odkaz:
https://doaj.org/article/45c7fff5573644268773a83e5bc85a03
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 10, Pp o1594-o1595 (2013)
The title N-benzylphthalimide derivative, C16H13NO3, consists of two planar moieties, viz. the phthalimide system (r.m.s. deviation = 0.007 Å) and the phenyl ring, which make a dihedral angle of 84.7 (6)°. The methoxy group is almost coplanar with
Externí odkaz:
https://doaj.org/article/940919d945bf445cade2d5545ca130af
Autor:
María Carmen Costas-Lago, Noemí Vila, Adeyemi Rahman, Pedro Besada, Isabel Rozas, José Brea, María Isabel Loza, Elisa González-Romero, Carmen Terán
Publikováno v:
Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Universidade de Vigo (UVigo)
Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7066827603577e414ee6bba4d163a0
https://hdl.handle.net/11093/3265
https://hdl.handle.net/11093/3265
Autor:
María Carmen, Costas-Lago, Noemí, Vila, Adeyemi, Rahman, Pedro, Besada, Isabel, Rozas, José, Brea, María Isabel, Loza, Elisa, González-Romero, Carmen, Terán
Publikováno v:
ACS medicinal chemistry letters. 13(3)
Novel aryl guanidinium analogues containing the pyridazin-3(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d8ea42c673b33af69d1337c64949c34
https://pubmed.ncbi.nlm.nih.gov/35300077
https://pubmed.ncbi.nlm.nih.gov/35300077
Autor:
Mattia Sturlese, Pedro Besada, Elias Quezada, Miguel Alonso-Pena, Stefano Moro, Carmen Terán, Dolores Viña, María Carmen Costas-Lago, Fernanda Rodríguez-Enríquez, José Angel Fontenla, Iria Torres-Terán
The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b018afc28f64a976fb7e7a10bc968
http://hdl.handle.net/11577/3349054
http://hdl.handle.net/11577/3349054
Autor:
Carmen Terán, Pedro Besada, Tamara Costas, Dolores Viña, María Carmen Costas-Lago, Noemí Vila, Mattia Sturlese, Stefano Moro, Iria Torres-Terán
Publikováno v:
Bioorganic Chemistry. 115:105203
A novel class of potential MAO-B inhibitors was designed and synthesized in good yield by combining the pyridazinone moiety with the dithiocarbamate framework, two relevant pharmacophores for drug discovery. The biological results obtained for the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91aab0f03c717c1c22e12527a7da4345
https://doi.org/10.1016/j.bioorg.2021.105203
https://doi.org/10.1016/j.bioorg.2021.105203
Publikováno v:
Future medicinal chemistry. 11(16)
Aim: The current limitations of antiplatelet therapy promote the search for new antithrombotic agents. Here we describe novel platelet aggregation inhibitors that combine pyridazinone and coumarin scaffolds in their structure. Results: The target com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e4b2aaf52f8b859bc4f8dd884d205
https://pubmed.ncbi.nlm.nih.gov/31538518
https://pubmed.ncbi.nlm.nih.gov/31538518
Autor:
Carmen Terán, Pedro Besada, Fernanda Borges, Fernanda Rodríguez-Enríquez, Dolores Viña, Santiago Vilar, Eugenio Uriarte, María Carmen Costas-Lago
Publikováno v:
European journal of medicinal chemistry. 139
Compounds of hybrid structure pyridazine-coumarin were discovered as potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B). These compounds were synthesized in good yield following a multistep approach based on Knoevenagel reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06ac60fadbff39e1895100c8846ab9e
https://pubmed.ncbi.nlm.nih.gov/28797881
https://pubmed.ncbi.nlm.nih.gov/28797881
Autor:
Tamara Costas, Pedro Besada, Carmen Terán, Ernesto Cano, María Carmen Costas-Lago, Noemí Vila
Publikováno v:
European journal of medicinal chemistry. 94
New series of pyridazinone derivatives (4, 5 and 6) were synthesized in good yields following a synthetic strategy based on singlet oxygen oxidation of alkyl furans, in which a suitable β(α)-substituted γ-hydroxybutenolide (10 or 11) or a bicyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085426bdfa07e9e95ed777d240282eac
https://pubmed.ncbi.nlm.nih.gov/25757094
https://pubmed.ncbi.nlm.nih.gov/25757094