Výsledky vyhledávání - "María C. Hyzinski-García"

Effects of alternative splicing on the function of bestrophin-1 calcium-activated chloride channels

Autor: Alexander A. Mongin, María C. Hyzinski-García, Iskandar F. Abdullaev, Yu-Hung Kuo

Publikováno v: Biochemical Journal. 458:575-583

The Bestrophin family is composed of four human genes that form transmembrane proteins [1-3]. When heteroexpressed in HEK293 cells, all four human Bestrophin genes produce novel and unique Cl− anion currents [4,5]. Mutations in one family member, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd845c43c85774c86cf9dc5e90ea18cb
https://doi.org/10.1042/bj20121546

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STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

Autor: Matthew M. Henkel, María C. Hyzinski-García, Iskandar F. Abdullaev, Mohamed Trebak, Rajender K. Motiani, Yu Hung Kuo, Xuexin Zhang, Khalid Matrougui, Alexander A. Mongin

Publikováno v: Pflügers Archiv - European Journal of Physiology. 465:1249-1260

The Ca(2+) sensor stromal interacting molecule 1 (STIM1) and the Ca(2+) channel Orai1 mediate the ubiquitous store-operated Ca(2+) entry (SOCE) pathway activated by depletion of internal Ca(2+) stores and mediated through the highly Ca(2+)-selective,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ec851964645b4ac8002f2faf762b42
https://doi.org/10.1007/s00424-013-1254-8

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Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures

Autor: Alexander A. Mongin, Richard W. Keller, María C. Hyzinski-García, Renée E. Haskew-Layton, Melanie Y. Vincent, Preeti Dohare

Publikováno v: Journal of Neurochemistry. 118:140-152

In our previous work, we found that perfusion of the rat cerebral cortex with hypo-osmotic medium triggers massive release of the excitatory amino acid L-glutamate but decreases extracellular levels of L-glutamine (R. E. Haskew-Layton et al., PLoS ON

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ac92126de954d37c2026257f0c5c6c
https://doi.org/10.1111/j.1471-4159.2011.07289.x

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LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes

Autor: María C. Hyzinski-García, Alexander A. Mongin, Alena Rudkouskaya

In mammals, cellular swelling activates release of small organic osmolytes, including the excitatory amino acids (EAA) glutamate and aspartate, via a ubiquitously expressed volume-regulated chloride/anion channel (VRAC). Pharmacological evidence sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafc978ac887456044b3662e3eaa1810
https://europepmc.org/articles/PMC4259531/

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The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke

Autor: Aarshi Vipani, Alexander A. Mongin, Nicole H. Bowens, Paul J. Feustel, Richard W. Keller, Preeti Dohare, María C. Hyzinski-García, David Jourd'heuil, Julia W. Nalwalk

Publikováno v: Free radical biologymedicine. 77

The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies failed to show benefits in human stroke. Based on our previous in vitro work, we hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501030e131cc4f93121d5ac96edad4a
https://pubmed.ncbi.nlm.nih.gov/25224033

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Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-L-lactic acid fibers

Autor: Jonathan M. Zuidema, Alexander A. Mongin, Kristien Van Vlasselaer, George E. Plopper, María C. Hyzinski-García, Nicholas W. Zaccor, Ryan J. Gilbert

Bioengineered fiber substrates are increasingly studied as a means to promote regeneration and remodeling in the injured central nervous system (CNS). Previous reports largely focused on the ability of oriented scaffolds to bridge injured regions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d6270fac4ece79db0b368114396b58
https://europepmc.org/articles/PMC4183153/

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A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells

Autor: Alexander A. Mongin, Richard W. Keller, María C. Hyzinski-García, Melanie Y. Vincent

Publikováno v: American journal of physiology. Cell physiology. 301(4)

Here we report and validate a simple method for measuring intracellular activities of glial glutamine synthetase (GS) and glutaminase (GLNase) in intact glial cells. These enzymes are responsible for glutamate and glutamine recycling in the brain, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda13e81bf0f077b2537561567009934
https://pubmed.ncbi.nlm.nih.gov/21734190

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Aromaticity at the water-hydrocarbon core interface of the membrane: Consequences on the nicotinic acetylcholine receptor

Autor: José E. Lizardi-Ortiz, José A. Lasalde-Dominicci, Karen M. Osorio-Martínez, María C. Hyzinski-García, Félix L. Valle-Avilés, José L. Fernández-Gerena, Eric Velázquez-Rivera

Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues flanking the hydrophobic segment of the domains. These residues generally reside close to the carbonyl region of the membrane, and several structural and fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8a53567506e12a03bf71cb7c2cb8f9
https://europepmc.org/articles/PMC3132569/

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