Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand.

Autor: Estefanía R Zacca, María I Crespo, Rachel P Acland, Emiliano Roselli, Nicolás G Núñez, Mariana Maccioni, Belkys A Maletto, María C Pistoresi-Palencia, Gabriel Morón

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140672 (2015)

The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting cells that play a key role in both adaptive and innate immunity, but how aging affects DCs and thei

Externí odkaz: https://doaj.org/article/0ddcb9694d7641a68e037090b50f94a6

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen

Autor: Ana L. Chiodetti, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Santiago D. Palma, María C. Pistoresi-Palencia, Gabriel Morón, Belkys A. Maletto

Publikováno v: Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology, Vol 9 (2018)

There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim, we formulated class-B synthetic oligodeoxynucleotide containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50104cf000db9a5910687f95a22edb25
http://europepmc.org/articles/PMC6192457

Association between levels of synovial anti-citrullinated peptide antibodies and neutrophil response in patients with rheumatoid arthritis

Autor: María I. Crespo, Héctor Tamashiro, Alicia Lavanchy, María Silvia Di Genaro, Rodolfo Pardo-Hildalgo, Mabel Noemí Dave, Carolina V Gorlino, María C. Pistoresi-Palencia, Rodrigo Blas

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated peptide antibodies (ACPAs) and neutrophils infiltrating the synovial fluid (SF) of the affected joints. The aim of this work was to analyze whether the presence of ACPAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786a6f6d087d382dc055fb195485ce57
Wiley Online Library

Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment

Autor: Carolina V. Gorlino, María I. Crespo, Romina P. Ranocchia, María C. Pistoresi-Palencia, Gabriel Morón, Belkys A. Maletto, María F. Harman, Sofía D. Castell, María F. Sánchez Vallecillo

Publikováno v: Oncotarget

As we age, the homeostatic function of many systems in the body, such as the immune function declines, which in turn contributes to augment susceptibility to disease. Here we describe that challenging aged mice with synthetic oligodeoxynucleotides co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c2829588527ad1c7a40502326fae2
http://europepmc.org/articles/PMC4537026

Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells

Autor: Gabriela Picotto, Ana C. Liaudat, María C. Pistoresi-Palencia, Belkys A. Maletto, Nori Tolosa de Talamoni, Luciana Bohl

Publikováno v: Anti-Cancer Drugs. 25:810-818

The prognosis and incidence of colon cancer are linked to vitamin D3 serum levels. To evaluate the effects of D,L-buthionine-S,R-sulfoximine (BSO), 1,25(OH)2D3 and their combination on intestinal Caco-2 cell growth, to elucidate the possible cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56df24215f4e3355bcf5b713e988802
https://doi.org/10.1097/cad.0000000000000109