ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

Autor: María Victoria Castro, Gastón Alexis Barbero, María Belén Villanueva, Luca Grumolato, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada, Pablo Lopez-Bergami

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)

Abstract Background Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to study the role of ROR2

Externí odkaz: https://doaj.org/article/4aa18ad8bb6d4dfa887f300feb49a3f7

An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma

Autor: Gastón Barbero, María Victoria Castro, María Belén Villanueva, María Josefina Quezada, Natalia Brenda Fernández, Sharon DeMorrow, Pablo Lopez-Bergami

Publikováno v: Cells, Vol 8, Iss 9, p 1060 (2019)

Wnt5a signaling has been implicated in the progression of cancer by regulating multiple cellular processes, largely migration and invasion, epithelial-mesenchymal transition (EMT), and metastasis. Since Wnt5a signaling has also been involved in infla

Externí odkaz: https://doaj.org/article/aa484f513be648769c11327e440497d5

ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma

Autor: María Victoria Castro, Gastón Alexis Barbero, Paula Máscolo, María Belén Villanueva, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada, Pablo Lopez-Bergami

Publikováno v: J Cell Commun Signal

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a protein with important functions during embryogenesis that is dysregulated in human cancer. An intriguing feature of this receptor is that it plays opposite roles in different tumor types ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b420c0ef834e96402ecab5ace3340e
https://pubmed.ncbi.nlm.nih.gov/35723796

ROR2 Promotes EMT and Necrosis by Hyperactivating ERK in Melanoma

Autor: Gastón Barbero, Pablo Lopez-Bergami, María Victoria Castro, María Belén Villanueva, Edith Illescas, Julia Newton-Bishop, María Josefina Quezada, Jérémie Nsengimana

PurposeReceptor tyrosine kinase-like orphan receptor 2 (ROR2) has been shown to play opposite roles in the progression of different tumor types. In melanoma, ROR2 was shown to associate with a more invasive phenotype and to contribute to experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7e4aac3ed74129caa1312b06a31958e
https://doi.org/10.21203/rs.3.rs-1050315/v1

STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1

Autor: María Victoria Castro, Natalia Fernández, Gastón Barbero, María Belén Villanueva, María Elisa Picco, María Josefina Quezada, Pablo Lopez-Bergami, Hyungsoo Kim

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell & Bioscience
Cell & Bioscience, Vol 9, Iss 1, Pp 1-14 (2019)

Background: The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activity induce changes in the same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16aa6b33f83567432a568fa68d8a652e
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-018-0265-8