Reduced expression of NO-sensitive guanylyl cyclase in reactive astrocytes of Alzheimer disease, Creutzfeldt–Jakob disease, and multiple sclerosis brains

Autor: María Antonia Baltrons, Paula Pifarré, Isidre Ferrer, José Miguel Carot, Agustina García

Publikováno v: Neurobiology of Disease, Vol 17, Iss 3, Pp 462-472 (2004)

In Alzheimer's disease (AD) brains increased NO synthase (NOS) expression is found in reactive astrocytes surrounding amyloid plaques. We have recently shown that treatment with β-amyloid peptides or IL-1β down-regulates NO-sensitive soluble guanyl

Externí odkaz: https://doaj.org/article/7141c4c1ad5e4529958c3d55c0594e08

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

Autor: Ottavio Arancio, Lydia Giménez-Llort, Victoria M. Clos, Victor J. Yuste, Jose R. Bayascas, J.R. Palacio, Sònia Pascual-Guiral, María Antonia Baltrons, Rebeca Ponce, Shaobin Yang

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Frontiers in Aging Neuroscience, Vol 9 (2018)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Frontiers in Aging Neuroscience

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dda251aa9af50ad9fad41418cb9189c
http://hdl.handle.net/2072/426296

NO-sensitive guanylyl cyclase β1 subunit is peripherally associated to chromosomes during mitosis. Novel role in chromatin condensation and cell cycle progression

Autor: Agustina García, María Antonia Baltrons, Paula Pifarré, Istvan Földi

Publikováno v: The International Journal of Biochemistry & Cell Biology. 41:1719-1730

NO-sensitive guanylyl cyclase (GC(NO)), the major NO target, is involved in important regulatory functions in the cardiovascular, gastrointestinal and central nervous systems. GC(NO) exists as heterodimers of alpha(1/2) and beta1 subunits. Deletion o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a611b9cdaf088f5ddbbc8b46e282c8aa
https://doi.org/10.1016/j.biocel.2009.02.022

The ANP-cGMP-protein kinase G pathway induces a phagocytic phenotype but decreases inflammatory gene expression in microglial cells

Autor: Mariela Susana Borán, María Antonia Baltrons, Agustina García

Publikováno v: Glia. 56:394-411

Reactive gliosis is a prominent feature of CNS injury that involves dramatic changes in glial cell morphology together with increased motility, phagocytic activity, and release of inflammatory mediators. We have recently demonstrated that stimulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23684b393f4c41eee902521978bc32d9
https://doi.org/10.1002/glia.20618

Nitric oxide-dependent and independent down-regulation of NO-sensitive guanylyl cyclase in neural cells

Autor: María Antonia Baltrons, Teresa Sardón, Agustina García

Publikováno v: Toxicology Letters. 149:75-83

NO-sensitive guanylyl cyclase or soluble guanylyl cyclase (sGC) is the major target for NO and cyclic GMP the mediator of its vasodilating and neuromodulatory actions. Studies on the mechanism of nitrovasodilator-induced tolerance have shown that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198c7f92032360003698c24992462951
https://doi.org/10.1016/j.toxlet.2003.12.021