Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells1[S]

Autor: Maria Laura Martin, Gerhard Liebisch, Stefan Lehneis, Gerd Schmitz, María Alonso-Sande, Joan Bestard-Escalas, Daniel H. Lopez, José Manuel García-Verdugo, Mario Soriano-Navarro, Xavier Busquets, Pablo V. Escribá, Gwendolyn Barceló-Coblijn

Publikováno v: Journal of Lipid Research, Vol 54, Iss 5, Pp 1457-1465 (2013)

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in tumor cells. In the present study, we investigated

Externí odkaz: https://doaj.org/article/423f21af19684f94966ca53cde2765d4

The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism

Autor: Francisca Guardiola-Serrano, David J. López, Silvia Terés, Rafael Álvarez, Roberto Beteta-Göbel, Maitane Ibarguren, Raquel Rodríguez-Lorca, Pablo V. Escribá, María Alonso-Sande, Xavier Busquets

Publikováno v: The Journal of pharmacology and experimental therapeutics. 354(2)

Membrane lipid therapy is a novel approach to rationally design or discover therapeutic molecules that target membrane lipids. This strategy has been used to design synthetic fatty acid analogs that are currently under study in clinical trials for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1cf1723206f447cdf95a9e7462c1fa
https://pubmed.ncbi.nlm.nih.gov/26065701

Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells

Autor: Joan Bestard-Escalas, Pablo V. Escribá, Mario Soriano-Navarro, Stefan Lehneis, Maria Laura Martin, Gerd Schmitz, Daniel H. Lopez, Xavier Busquets, José Manuel García-Verdugo, Gwendolyn Barceló-Coblijn, María Alonso-Sande, Gerhard Liebisch

Publikováno v: JOURNAL OF LIPID RESEARCH
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
The Journal of Lipid Research; Vol 54

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in tumor cells. In the present study, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8b0ab32d291fc649c59d66affdc39b
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2028