Zobrazeno 1 - 10
of 177
pro vyhledávání: '"María A. Pajares"'
Autor:
Patricia González-Jiménez, Sofia Duarte, Alma E. Martínez, Elena Navarro-Carrasco, Vasiliki Lalioti, María A. Pajares, Dolores Pérez-Sala
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102756- (2023)
Cysteine residues can undergo multiple posttranslational modifications with diverse functional consequences, potentially behaving as tunable sensors. The intermediate filament protein vimentin has important implications in pathophysiology, including
Externí odkaz:
https://doaj.org/article/358067c83a984068ab790405ef783881
Autor:
Vasiliki Lalioti, Silvia González-Sanz, Irene Lois-Bermejo, Patricia González-Jiménez, Álvaro Viedma-Poyatos, Andrea Merino, María A. Pajares, Dolores Pérez-Sala
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The SARS-CoV-2 Spike protein mediates docking of the virus onto cells prior to viral invasion. Several cellular receptors facilitate SARS-CoV-2 Spike docking at the cell surface, of which ACE2 plays a key role in many cell types. The interme
Externí odkaz:
https://doaj.org/article/bbf322cc1241404b9e9a889e1b6e17a6
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102415- (2022)
Alexander disease is a fatal neurological disorder caused by mutations in the intermediate filament protein Glial Fibrillary Acidic Protein (GFAP), which is key for astrocyte homeostasis. These mutations cause GFAP aggregation, astrocyte dysfunction
Externí odkaz:
https://doaj.org/article/b98c4a9ec5cd4c04bf251c9728dc6549
Autor:
Irene Lois-Bermejo, Patricia González-Jiménez, Sofia Duarte, María A. Pajares, Dolores Pérez-Sala
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The intermediate filament protein vimentin plays a key role in cell signaling and stress sensing, as well as an integrator of cytoskeletal dynamics. The vimentin monomer consists of a central rod-like domain and intrinsically disordered head and tail
Externí odkaz:
https://doaj.org/article/86a4313796324e2fafd48860fb18f92c
Autor:
Dolores Pérez-Sala, María A. Pajares
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8059 (2023)
The metabolism and intercellular transfer of glutathione or its precursors may play an important role in cellular defense against oxidative stress, a common hallmark of neurodegeneration. In the 1990s, several studies in the Neurobiology field led to
Externí odkaz:
https://doaj.org/article/3705a02c22874ec8b52d6ac8b1836f23
Autor:
Juan M. González-Morena, Francisco J. Sánchez-Gómez, Yolanda Vida, Ezequiel Pérez-Inestrosa, María Salas, María I. Montañez, Alessandra Altomare, Giancarlo Aldini, María A. Pajares, Dolores Pérez-Sala
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the modification of proteins by c
Externí odkaz:
https://doaj.org/article/dca58d595c514fb59582cecf556410c6
Autor:
Sofia Duarte, Álvaro Viedma-Poyatos, Elena Navarro-Carrasco, Alma E. Martínez, María A. Pajares, Dolores Pérez-Sala
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The intermediate filament vimentin reorganizes during mitosis, but its molecular regulation and impact on the cell during cell division is unclear. Here, the authors show that vimentin filaments redistribute to the cell cortex during mitosis intertwi
Externí odkaz:
https://doaj.org/article/cf82cdd422be4ec5b5be0ecec294164e
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101582- (2020)
Intermediate filaments (IFs) play key roles in cell mechanics, signaling and homeostasis. Their assembly and dynamics are finely regulated by posttranslational modifications. The type III IFs, vimentin, desmin, peripherin and glial fibrillary acidic
Externí odkaz:
https://doaj.org/article/a8a5aed504024cc2b376c40001236921
Autor:
María A. Pajares, Tahl Zimmerman, Francisco J. Sánchez-Gómez, Adriana Ariza, María J. Torres, Miguel Blanca, F. Javier Cañada, María I. Montañez, Dolores Pérez-Sala
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies explo
Externí odkaz:
https://doaj.org/article/3ce8a42f59d342d7b2d586d943532fce
Autor:
Andreia Mónico, Joan Guzmán-Caldentey, María A. Pajares, Sonsoles Martín-Santamaría, Dolores Pérez-Sala
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1039 (2021)
The intermediate filament protein vimentin is involved in essential cellular processes, including cell division and stress responses, as well as in the pathophysiology of cancer, pathogen infection, and autoimmunity. The vimentin network undergoes ma
Externí odkaz:
https://doaj.org/article/972c9988f8484c658b2df4ed66d87b58