Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Autor: Raquel García, Ana B. Salido-Medina, Aritz Gil, David Merino, Jenny Gómez, Ana V. Villar, Francisco González-Vílchez, María A. Hurlé, J. Francisco Nistal

Publikováno v: Cells, Vol 9, Iss 4, p 833 (2020)

Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle (LV) in a sex-specific manner. We assessed whether a sex-specific miR-29b dysregulation underlies this sex-biased remodeling pattern, as has b

Externí odkaz: https://doaj.org/article/c67ec688d3cb412ea8bcc36380edf94a

Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Autor: Aritz Gil, Raquel García, Francisco González-Vílchez, David Merino, Ana V. Villar, Ana B. Salido-Medina, J. Francisco Nistal, María A. Hurlé, J. Gómez

Publikováno v: Cells
Cells 2020, 9(4), 833
UCrea Repositorio Abierto de la Universidad de Cantabria
instname
Cells, Vol 9, Iss 833, p 833 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
Volume 9
Issue 4

Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle (LV) in a sex-specific manner. We assessed whether a sex-specific miR-29b dysregulation underlies this sex-biased remodeling pattern, as has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad624b53bb755759e250335db300e0c
http://europepmc.org/articles/PMC7226763

Plasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosis.

Autor: Ana V Villar, Manuel Cobo, Miguel Llano, Cecilia Montalvo, Francisco González-Vílchez, Rafael Martín-Durán, María A Hurlé, J Francisco Nistal

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8476 (2009)

BackgroundTGF-beta1 is involved in cardiac remodeling through an auto/paracrine mechanism. The contribution of TGF-beta1 from plasmatic source to pressure overload myocardial remodeling has not been analyzed. We investigated, in patients with valvula

Externí odkaz: https://doaj.org/article/b69c4889c40646068e960877e82eb065

BMP-7 protects male and female rodents against neuropathic pain induced by nerve injury through a mechanism mediated by endogenous opioids

Autor: Rosmarí de la Puerta, Mónica Tramullas, Roberto de la Fuente, Raquel Francés, María Carcelén, María A. Hurlé

Publikováno v: Pharmacological Research. 150:104470

Neuropathic pain is highly prevalent in pathological conditions such as diabetes, herpes zoster, trauma, etc. The severity and refractoriness to treatments make neuropathic pain a significant health concern. The transforming growth factor (TGF-β) fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca3aa24be79531e83d1ff9a9ead53e7
https://doi.org/10.1016/j.phrs.2019.104470

Experimental modelling of cardiacpressure overload hypertrophy: Modified technique for precise,reproducible, safe and easy aorticarch banding-debanding in mice

Autor: J. Gómez, David Merino, Miguel Llano, Raquel García, Luis Santiago Sazatornil Ruiz, Aritz Gil, María A. Hurlé, J. Francisco Nistal

Publikováno v: Sci Rep 2018, 8 (1), 3167
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Pressure overload left ventricular hypertrophy is a known precursor of heart failure with ominous prognosis. The development of experimental models that reproduce this phenomenon is instrumental for the advancement in our understanding of its pathoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c74ebfba004ccaac5345763cb6d3f3
http://hdl.handle.net/10902/17593