Zobrazeno 1 - 10
of 18
pro vyhledávání: '"María A. Cobos-Fernández"'
Autor:
Iria González-Vasconcellos, María A. Cobos-Fernández, Michael J. Atkinson, José Fernandez-Piqueras, Javier Santos
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-7 (2022)
Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Externí odkaz:
https://doaj.org/article/de71886261e241c3871c6808910372cb
Autor:
Pilar López-Nieva, Iria González-Vasconcellos, Laura González-Sánchez, María A. Cobos-Fernández, Sara Ruiz-García, Raúl Sánchez Pérez, Ángel Aroca, José Fernández-Piqueras, Javier Santos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In the quest for more effective radiation treatment options that can improve both cell killing and healthy tissue recovery, combined radiation therapies are lately in the spotlight. The molecular response to a combined radiation regime where
Externí odkaz:
https://doaj.org/article/f67abbf5a64040c4a4c1b91f3827cade
Autor:
Pablo Fernández-Navarro, Pilar López-Nieva, Elena Piñeiro-Yañez, Gonzalo Carreño-Tarragona, Joaquín Martinez-López, Raúl Sánchez Pérez, Ángel Aroca, Fátima Al-Shahrour, María Ángeles Cobos-Fernández, José Fernández-Piqueras
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity of current protocols
Externí odkaz:
https://doaj.org/article/4844963c8bf847eb979d9da891212543
Autor:
Antonio Lahera, Pilar López‐Nieva, Hernán Alarcón, José L. Marín‐Rubio, María Á. Cobos‐Fernández, Pablo Fernández‐Navarro, Agustín F. Fernández, Laura Vela‐Martín, Isabel Sastre, Sara Ruiz‐García, Pilar Llamas, José L. López‐Lorenzo, Javier Cornago, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales
Publikováno v:
Scopus
Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T-ALL/LBL, no specific therapy has been approved for T-ALL/LBL patients with constitutive signalling by JAK/STAT, so there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71d0f2b00cba28da6de3f3d19757bf6
https://doi.org/10.1111/bjh.18694
https://doi.org/10.1111/bjh.18694
Autor:
Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in the
Externí odkaz:
https://doaj.org/article/8c05930c4cca48cc98e127c09078321c
Autor:
Javier Santos, Laura González-Sánchez, Pilar López-Nieva, María Ángeles Cobos-Fernández, Raúl Córdoba, José Fernández-Piqueras
Publikováno v:
The Oncologist
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
The NOTCH1 gene encodes a transmembrane receptor protein with activating mutations observed in many T‐cell acute lymphoblastic leukemias (T‐ALLs) and lymphomas, as well as in other tumor types, which has led to interest in inhibiting NOTCH1 signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36aa9603658f5486633fcf1b321f398
http://europepmc.org/articles/PMC7873333
http://europepmc.org/articles/PMC7873333
Autor:
Pilar López-Nieva, Pablo Fernández-Navarro, María Ángeles Cobos-Fernández, Iria González-Vasconcellos, Raúl Sánchez Pérez, Ángel Aroca, José Fernández-Piqueras, Javier Santos
Publikováno v:
Non-Coding RNA; Volume 8; Issue 2; Pages: 26
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Circular RNAs (circRNAs) are suggested to play a discriminative role between some stages of thymocyte differentiation. However, differential aspects of the stage of mature single-positive thymocytes remain to be explored. The purpose of this study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fc6768b24a8e569233098222352cbf
Autor:
José Luis Marín-Rubio, Konstantinos Stamatakis, Javier Santos, María Villa-Morales, José M. Cuezva, José Fernández-Piqueras, Eduardo Salido, Pilar Llamas, Iria Gonzalez-Vasconcellos, José Luis López-Lorenzo, Laura González-Sánchez, María Ángeles Cobos-Fernández, Irene Vázquez-Domínguez, Pilar López-Nieva
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6b12e8f4e23fb7f67c6cfb6817ef35
https://doi.org/10.1093/carcin/bgz185
https://doi.org/10.1093/carcin/bgz185
Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma
Autor:
Javier Santos, Laura González-Sánchez, José Luis López-Lorenzo, Isabel Sastre, María Villa-Morales, Mario F. Fraga, María Salazar-Roa, Pilar Llamas, Agustín F. Fernández, Irene Vázquez-Domínguez, Osvaldo Graña-Castro, José Fernández-Piqueras, Pablo Fernández-Navarro, Pilar López-Nieva, María Ángeles Cobos-Fernández, Marcos Malumbres
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
FBXW7 is a driver gene in T-cell lymphoblastic neoplasia acting through proteasome degradation of key proto-oncogenes. FBXW7 encodes three isoforms, α, β and γ, which differ only in the N-terminus. In this work, massive sequencing revealed signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfb40b52ec98709e9d93efff9f93692
https://doi.org/10.1038/s41388-019-0746-1
https://doi.org/10.1038/s41388-019-0746-1
Autor:
Ángel Aroca, Raúl Sánchez Pérez, Elena Piñeiro-Yáñez, Pablo Fernández-Navarro, Gonzalo Carreño-Tarragona, Pilar López-Nieva, María Ángeles Cobos-Fernández, Fatima Al-Shahrour, José Fernández-Piqueras, Joaquin Martinez-Lopez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer
[Background] Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity of current protocols and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de40e0ed8398dc753948f4c6e76a096b
http://hdl.handle.net/10261/193534
http://hdl.handle.net/10261/193534
