Výsledky vyhledávání - "María Isabel Cadavid"

Akademický článek

Adecuación de la prescripción en pacientes mayores polimedicados en atención primaria. Ensayo clínico controlado aleatorizado por grupos PHARM-PC

Autor: Jesús Martínez-Sotelo, Manuel Pinteño-Blanco, Rosario García-Ramos, María Isabel Cadavid-Torres

Publikováno v: Atención Primaria, Vol 53, Iss 10, Pp 102124- (2021)

Resumen: Objetivos: Evaluar la efectividad de la revisión sistemática de medicación realizada por farmacéutico sobre medicaciones potencialmente inapropiadas (MPI), resultados en salud y costes. Diseño: Ensayo clínico prospectivo, abierto, cont

Externí odkaz: https://doaj.org/article/ec13c2c98e5d449188c0e00fd88e1a1a

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Adecuación de la prescripción en pacientes mayores polimedicados en atención primaria. Ensayo clínico controlado aleatorizado por grupos PHARM-PC

Autor: Manuel Pinteño-Blanco, María Isabel Cadavid-Torres, Jesús Martínez-Sotelo, Rosario García-Ramos

Publikováno v: Atención Primaria, Vol 53, Iss 10, Pp 102124-(2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e0a17b64fbdc566fe59f9e2875c92e
http://www.sciencedirect.com/science/article/pii/S021265672100158X

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Pharmacist-led intervention on potentially inappropriate prescription in patients with polypharmacy: PHARM-PC clinical trial protocol

Autor: Jesús, Martínez-Sotelo, Manel, Pinteño-Blanco, Rosario, García-Ramos, Joan, Llobera-Cànaves, María Isabel, Cadavid-Torres

Publikováno v: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 45(4)

Polypharmacy and potentially inappropriate medications (that is, those associated with an unfavorable risk-benefit ratio) are common concerns in the context of elderly patients treated in primary care as they may increase the risk of morbidity and mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dea085c783709490b6daf07aa3a59141
https://pubmed.ncbi.nlm.nih.gov/34218768

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Akademický článek

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

Autor: Ana M. García, José Brea, Alejandro González-García, Concepción Pérez, María Isabel Cadavid, María Isabel Loza, Ana Martinez, Carmen Gil

Publikováno v: Molecules, Vol 22, Iss 9, p 1472 (2017)

Phosphodiesterase (PDE) enzymes regulate the levels of cyclic nucleotides, cAMP, and/or cGMP, being attractive therapeutic targets. In order to modulate PDE activity in a selective way, we focused our efforts on the search of allosteric modulators. B

Externí odkaz: https://doaj.org/article/639d5c4f602e435fad3f53935fb52770

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[Prescription appropriateness in elderly patients with polypharmacy in primary care: Cluster-randomized controlled trial PHARM-PC]

Autor: Jesús, Martínez-Sotelo, Manuel, Pinteño-Blanco, Rosario, García-Ramos, María Isabel, Cadavid-Torres

Publikováno v: Atencion Primaria

Objetivos Evaluar la efectividad de la revisión sistemática de medicación realizada por farmacéutico sobre medicaciones potencialmente inapropiadas (MPI), resultados en salud y costes. Diseño Ensayo clínico prospectivo, abierto, controlado y al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::174f0e45bcb11335cafe139b7847cda3
https://pubmed.ncbi.nlm.nih.gov/34488034

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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor

Autor: Juan F. López-Giménez, María Isabel Cadavid, José Brea, María Isabel Loza, Marián Castro, Antón L. Martínez, L. Gómez-García, Marta Cimadevila, Alba Iglesias

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The 5-HT receptor is a homodimeric G protein-coupled receptor implied in multiple diseases, including schizophrenia. Recently, its co-crystallisation with the antipsychotic drugs zotepine and risperidone has revealed the importance of its extracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a929469e3c7879c7e588b37e2699b20
http://hdl.handle.net/10261/216310

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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization

Autor: María Isabel Loza, María Isabel Cadavid, Jana Selent, Marta Cimadevila, Marián Castro, Maria Marti-Solano, José Brea, Rocio A. de la Fuente, Alba Iglesias

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
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The serotonin 2A (5-HT2A) receptor is a G-protein coupled receptor (GPCR) with a conserved disulfide bridge formed by Cys148 (transmembrane helix 3, TM3) and Cys227 (extracellular loop 2, ECL-2). We hypothesized that disulfide bridges may determine s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1761bfca50f73c44aa13e02ffc82d1
https://doi.org/10.1016/j.ejphar.2017.09.011

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Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists

Autor: Eddy Sotelo, Johan Åqvist, Vicente Yaziji, Hugo Gutiérrez-de-Terán, Ana Mallo, María Majellaro, María Isabel Cadavid, Willem Jespers, Olga Caamaño, María Isabel Loza, José Brea, Jhonny Azuaje

Publikováno v: Journal of Medicinal Chemistry. 60:7502-7511

We report the first family of 2-acetamidopyridines as potent and selective A3 adenosine receptor (AR) antagonists. The computer-assisted design was focused on the bioisosteric replacement of the N1 atom by a CH group in a previous series of diarylpyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ee66046dc5144fdc2cde2bdb32f199a
https://doi.org/10.1021/acs.jmedchem.7b00860

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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

Autor: Christian F. Masaguer, Carlos Carbajales, María Isabel Cadavid, Xerardo García-Mera, Eddy Sotelo, Ana Oliveira, Hugo Gutiérrez-de-Terán, José Brea, María Isabel Loza, Jhonny Azuaje

Publikováno v: Journal of Medicinal Chemistry. 60:3372-3382

A novel family of structurally simple, potent, and selective nonxanthine A2BAR ligands was identified, and its antagonistic behavior confirmed through functional experiments. The reported alkyl 2-cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahy-drop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56a48f964050358308eaef7e39c53c58
https://doi.org/10.1021/acs.jmedchem.7b00138

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Serotonin-2A homodimers are needed for signalling via both phospholipase A 2 and phospholipase C in transfected CHO cells

Autor: Marta Cimadevila, María Isabel Loza, Alba Iglesias, José Brea, María Isabel Cadavid

Publikováno v: European Journal of Pharmacology. 800:63-69

Different ligands differentially activate phospholipase A2 (PLA2) and phospholipase C (PLC) signalling pathways that are coupled to the serotonin 2A (5-HT2A) receptor, a class-A G-protein coupled receptor (GPCR). The serotonin 5-HT2A receptor has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c778de28f1ed841c318e8f9445cd77ea
https://doi.org/10.1016/j.ejphar.2017.02.028

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