Hybrid Cyclobutane/Proline-Containing Peptidomimetics: The Conformational Constraint Influences Their Cell-Penetration Ability

Autor: Ona Illa, Jimena Ospina, José-Emilio Sánchez-Aparicio, Ximena Pulido, María Ángeles Abengozar, Nerea Gaztelumendi, Daniel Carbajo, Carme Nogués, Luis Rivas, Jean-Didier Maréchal, Miriam Royo, Rosa M. Ortuño

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10, p 5092 (2021)

A new family of hybrid β,γ-peptidomimetics consisting of a repetitive unit formed by a chiral cyclobutane-containing trans-β-amino acid plus a Nα-functionalized trans-γ-amino-l-proline joined in alternation were synthesized and evaluated as cell

Externí odkaz: https://doaj.org/article/581a1c699e134a00ba99da9a678902a5

Chiral Cyclobutane-Containing Cell-Penetrating Peptides as Selective Vectors for Anti-Leishmania Drug Delivery Systems

Autor: Carme Nogués, María-Ángeles Abengozar, Ona Illa, Luis Rivas, Jean-Didier Maréchal, Giuseppe Sciortino, Nerea Gaztelumendi, José Antonio Olivares, Laura Martínez-Castro, Miriam Royo, Rosa M. Ortuño, Jimena Ospina

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
International Journal of Molecular Sciences, Vol 21, Iss 7502, p 7502 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 20

Two series of new hybrid &gamma
/&gamma
peptides, &gamma
CC and &gamma
CT, formed by (1S,2R)-3-amino-2,2,dimethylcyclobutane-1-carboxylic acid joined in alternation to a N&alpha
functionalized cis- or trans-&gamma
amino-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea51ef536f10530f98f4779cf926f0a6
https://ddd.uab.cat/record/233888