Proteomics analysis of the p.G849D variant in neurexin 2 alpha may reveal insight into Parkinson’s disease pathobiology

Autor: Katelyn Cuttler, Suereta Fortuin, Amica Corda Müller-Nedebock, Maré Vlok, Ruben Cloete, Soraya Bardien

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

Parkinson’s disease (PD), the fastest-growing neurological disorder globally, has a complex etiology. A previous study by our group identified the p.G849D variant in neurexin 2 (NRXN2), encoding the synaptic protein, NRXN2α, as a possible causal v

Externí odkaz: https://doaj.org/article/5a527963734145f785ab73a9e7538fe9

Wheat Line 'RYNO3936' Is Associated With Delayed Water Stress-Induced Leaf Senescence and Rapid Water-Deficit Stress Recovery

Autor: Marlon-Schylor L. le Roux, N. Francois V. Burger, Maré Vlok, Karl J. Kunert, Christopher A. Cullis, Anna-Maria Botha

Publikováno v: Frontiers in Plant Science, Vol 11 (2020)

Random mutagenesis was applied to produce a new wheat mutant (RYNO3926) with superior characteristics regarding tolerance to water deficit stress induced at late booting stage. The mutant also displays rapid recovery from water stress conditions. Und

Externí odkaz: https://doaj.org/article/72d1458b6095466093de683d165edd4e

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Autor: Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

Publikováno v: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, orthostatic intolerance, and other

Externí odkaz: https://doaj.org/article/c26ec39aa27443d79bc13b36befb76af

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

Autor: Chantelle Venter, Douglas B. Kell, Janami Steenkamp, Etheresia Pretorius, Gert Jacobus Laubscher, Johannes A. Bezuidenhout, Maré Vlok

Publikováno v: Cardiovascular Diabetology
Pretorius, E, Vlok, M, Venter, C, Bezuidenhout, J A, Laubscher, G J, Steenkamp, J & Kell, D B 2021, ' Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin ', Cardiovascular Diabetology, vol. 20, 172 . https://doi.org/10.1186/s12933-021-01359-7
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-18 (2021)

Background Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by acute clinical pathologies, including various coagulopathies that may be accompanied by h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee7493a1bc4c18547adb7682e8dc31
http://europepmc.org/articles/PMC8381139

EMS Derived Wheat Mutant BIG8-1 (Triticum aestivum L.)—A New Drought Tolerant Mutant Wheat Line

Autor: Maré Vlok, Nicolas Francois V Burger, Christopher A. Cullis, Anna-Maria Botha, Karl J. Kunert, Marlon-Schylor L. le Roux

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5314, p 5314 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 10

Drought response in wheat is considered a highly complex process, since it is a multigenic trait
nevertheless, breeding programs are continuously searching for new wheat varieties with characteristics for drought tolerance. In a previous study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c946dd02896daf749d952f99d49c2e29
https://www.mdpi.com/1422-0067/22/10/5314