Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Mappicine ketone"'
Publikováno v:
Journal of the Chinese Chemical Society. 55:431-434
Various 4,5-disubstituted-3-sulfonyl glutarimides 3 were synthesized from α-sulfonyl acetamide 1 and ethyl α,β-disubstituted acrylate esters 2 via stepwise facile [3+3] annulation in moderate yield. The synthesis of pyridin-2-one 9, a key intermed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2eaf83d395d4df8d68656de77acc42d
https://doi.org/10.1002/jccs.200800064
https://doi.org/10.1002/jccs.200800064
Autor:
Oscar de Frutos and, Dennis P. Curran
Publikováno v:
Journal of Combinatorial Chemistry. 2:639-649
An improved cascade radical annulation route to (+/-)-mappicine, (S)-mappicine, and mappicine ketone is reported. The route is used to prepare libraries of mappicine and mappicine ketone analogues in a semiautomated fashion. Key diversity generating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf81d18fa1fada23193a6f6da236687
https://doi.org/10.1021/cc000032i
https://doi.org/10.1021/cc000032i
Autor:
Biswanath Das, P. Madhusudhan
Publikováno v:
Synthetic Communications. 30:3321-3325
Silica gel supported sodium hydrogen sulfate (NaHSO4.SiO2) catalyst has been utilized for the conversion of camptothecin and 9-methoxycamptothecin to mappicine ketone, an antiviral lead compound and its analogue, 9-methoxymappicine ketone respectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c727805c08fad9146ff9a404f3b157
https://doi.org/10.1080/00397910008086972
https://doi.org/10.1080/00397910008086972
Autor:
Biswanath Das, P. Madhusudhan
Publikováno v:
Tetrahedron. 55:7875-7880
The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to ( S )- and ( R )-mappicines in high optical purity using baker's yeast and a lipase, Amano PS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8dfa8e5ee1296dc18615f8bab3e73b2
https://doi.org/10.1016/s0040-4020(99)00397-x
https://doi.org/10.1016/s0040-4020(99)00397-x
Autor:
Dale L. Boger
Publikováno v:
Journal of Heterocyclic Chemistry. 35:1003-1011
A summary of the applications of the inverse electron demand Diels-Alder reactions of heterocyclic and acyclic azadienes in the total synthesis of natural products is provided and a recent application in the total synthesis of nothapodytine B (mappic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf05b310e6a14ed54916a118abf817b
https://doi.org/10.1002/jhet.5570350502
https://doi.org/10.1002/jhet.5570350502
Autor:
Dale L. Boger, Jiyong Hong
Publikováno v:
Journal of the American Chemical Society. 120:1218-1222
Concise total syntheses of naturally occurring nothapodytine B (1, mappicine ketone) and (−)-mappicine (3) are detailed. The approach is based on the implementation of a room-temperature, inverse e...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2795bc2e3f526634b0551796898cedf9
https://doi.org/10.1021/ja973007y
https://doi.org/10.1021/ja973007y
Autor:
Hubert Josien, Dennis P. Curran
Publikováno v:
Tetrahedron. 53:8881-8886
( S )-Mappicine ( 2 ) and mappicine ketone ( 1 ) have been prepared from methylacetoacetate ( 4 ) by a strategy featuring a radical cascade reaction of an isonitrile as the key step. The introduction of the hydroxy group of ( S )-mappicine occurred w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db76f6502b3f964caeecb2d527152d3
https://doi.org/10.1016/s0040-4020(97)90398-7
https://doi.org/10.1016/s0040-4020(97)90398-7
Autor:
Subhash P. Chavan, Rasapalli Sivappa
Publikováno v:
Tetrahedron Letters. 45:3941-3943
A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B ( 2 , mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2adbee0295a4ca6b678092ca6e8b6bdc
https://doi.org/10.1016/j.tetlet.2004.03.089
https://doi.org/10.1016/j.tetlet.2004.03.089
Publikováno v:
The Journal of Organic Chemistry. 60:2912-2915
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc78acf45ef5e0d565c852fe692b166f
https://doi.org/10.1021/jo00114a050
https://doi.org/10.1021/jo00114a050
Publikováno v:
Tetrahedron Letters. 42:931-933
Enamides 10, upon treatment with Bu3SnH–AIBN, gave 5-exo aryl radical cyclization products 11, which were partially desulfurized to give 1-substituted dihydroisoindoles 7 and 12. This method was applied to the synthesis of a model compound 4 of map
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb2fde14ab1c6ad5a334be39bfcbc06
https://doi.org/10.1016/s0040-4039(00)02138-9
https://doi.org/10.1016/s0040-4039(00)02138-9