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Akademický článek

The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review

Autor: Xiaoke Dou, Rui Chen, Juexi Yang, Maosha Dai, Junhao Long, Shujun Sun, Yun Lin

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of

Externí odkaz: https://doaj.org/article/bfbca0d2cd2d4437beee8db85170918c

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Akademický článek

Efficacy and safety evaluation of dexmedetomidine for postoperative patient controlled intravenous analgesia: A systematic review and meta-analysis

Autor: Rui Chen, Shujun Sun, Yufan Li, Xiaoke Dou, Maosha Dai, Yan Wu, Yun Lin

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Objective: To investigate the efficacy and safety of dexmedetomidine (DEX) for postoperative patient controlled intravenous analgesia (PCIA).Measurements: Two investigators independently searched Pubmed, Embase, Scopus, Cochrane Library and CBM for r

Externí odkaz: https://doaj.org/article/7cacc1a5ecbb453f8259db7bb3c807ac

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Akademický článek

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway

Autor: Li Wang, Maosha Dai, Yangyang Ge, Jiayi Chen, Chenchen Wang, Chengye Yao, Yun Lin

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Stroke remains one of the leading reasons of mortality and physical disability worldwide. The treatment of cerebral ischemic stroke faces challenges, partly due to a lack of effective treatments. In this study, we demonstrated that autophagy was stim

Externí odkaz: https://doaj.org/article/5953d1166fdf405a8684c6db9f2f6742

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Akademický článek

Effects of Dexmedetomidine on Immune Cells: A Narrative Review

Autor: Rui Chen, Yan Sun, Jing Lv, Xiaoke Dou, Maosha Dai, Shujun Sun, Yun Lin

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

As we all know, dexmedetomidine (DEX), as a highly selective α2 adrenergic receptor agonist, exerts sedative, anti-anxiety and hypnotic effects by inhibiting the discharge of norepinephrine neurons in locus coeruleus and GABA-related hypnotic pathwa

Externí odkaz: https://doaj.org/article/ed22c1eb120644c299052cce9bc619e9

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Akademický článek

γδ T Cell in Cerebral Ischemic Stroke: Characteristic, Immunity-Inflammatory Role, and Therapy

Autor: Li Wang, Chengye Yao, Jiayi Chen, Yangyang Ge, Chenchen Wang, Yu Wang, Fuquan Wang, Yan Sun, Maosha Dai, Yun Lin, Shanglong Yao

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

Gamma-delta (γδ) T cells are a small subset of T cells that are reported to have a proinflammatory role in the pathophysiology of cerebral ischemia stroke (CIS). Upon activation by interleukin-1 beta (IL-1β), IL-23 and IL-18, γδ T cells are stim

Externí odkaz: https://doaj.org/article/c249cc67271b477985b854dfe8edfcc8

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Evaluation of the Efficacy of Dexmedetomidine as a Local Anesthetic Adjuvant in Children: A Meta‐Analysis of Randomized Controlled Trials

Autor: Yan Sun, Zhilin Wu, ShuJun Sun, Rui Chen, Maosha Dai, Xiaoke Dou, Yun Lin

Publikováno v: The Journal of Clinical Pharmacology. 62:935-947

Dexmedetomidine has been identified as a useful adjunct to improve the effect of nerve blocks in adults; however, its effect for children has not yet been fully investigated. This meta-analysis aimed to evaluate the reliability and efficacy of dexmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897c30551f27da61a94774bfdcf19cce
https://doi.org/10.1002/jcph.2039

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Immunoregulatory mechanism of acute kidney injury in sepsis: A Narrative Review

Autor: Shujun Sun, Rui Chen, Xiaoke Dou, Maosha Dai, Junhao Long, Yan Wu, Yun Lin

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 159

Sepsis acute kidney injury (SAKI) is a common complication of sepsis, accounting for 26-50 % of all acute kidney injury (AKI). AKI is an independent risk factor for increased mortality risk in patients with sepsis. The excessive inflammatory cascade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c69522326f98aef9985d1948cd50da
https://pubmed.ncbi.nlm.nih.gov/36621143

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Identification of key genes and pathways in postoperative cognitive dysfunction: Potential therapeutic drugs discovered using bioinformatics analysis

Autor: Xiaoke Dou, Maosha Dai, Jiamin Ma, Yan Sun, Rui Chen, Yun Lin

Background: Postoperative cognitive dysfunction (POCD) is a common complication after general anesthesia surgery, and the mechanism of POCD has not been completely studied yet. We aim to use bioinformatics to identify the potential key genes and path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eccd5b91afca40fbb95536ba19dee5e
https://doi.org/10.21203/rs.3.rs-1371727/v1

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CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke

Autor: Yangyang, Ge, Li, Wang, Chenchen, Wang, Jiayi, Chen, Maosha, Dai, Shanglong, Yao, Yun, Lin

Publikováno v: Life Sciences. 300:120564

Stroke represents the second cause of mortality across the globe and develops following the interruption of cerebral blood circulation. The chemokine CX3CL1 and its receptor CX3CR1 play a fundamental role in the pathophysiology of ischemic stroke. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d380e4024c79c3ca546a4e21d791fb9
https://doi.org/10.1016/j.lfs.2022.120564

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