Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maohua Cai"'
Autor:
Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan, Xiang‑Dong Cheng, Jiang‑Jiang Qin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2004-2016 (2022)
Gastric cancer remains a significant health burden worldwide. In continuation of our previous study and development of effective small molecules against gastric cancer, a series of benzochalcone analogues involving heterocyclic molecules were synthes
Externí odkaz:
https://doaj.org/article/59f779a14cb74fd68b924c8ac81f8a4e
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leadi
Externí odkaz:
https://doaj.org/article/e9cc8938741d4e12bad704c531da07eb
Autor:
Dehua Yu, Simin Qi, Xiaoqing Guan, Wenkai Yu, Xuefei Yu, Maohua Cai, Qinglin Li, Weiyi Wang, Weidong Zhang, Jiang-Jiang Qin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Gastric cancer is a common type of malignant tumor with a relatively poor prognosis and presents a serious threat to global health. Signal Transducer and Activator of Transcription-3 (STAT3) has been strongly implicated in many cancers, and its const
Externí odkaz:
https://doaj.org/article/a8386e640ca043f1a8d1701330c05837
Publikováno v:
Current Medicinal Chemistry. 29:4391-4409
Abstract: Bromodomain and extra-terminal domain (BET) proteins are a well-studied family of proteins associated with a variety of diseases, including malignancy and chronic inflammation. Currently, numerous pan BET inhibitors have exhibited potent ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07cbc052f19d7ad96717b07d7272d06
https://doi.org/10.2174/0929867329666220211091806
https://doi.org/10.2174/0929867329666220211091806
Publikováno v:
Bioorganic & Medicinal Chemistry. 90:117352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b60fa11f4ff5257ff5ffbab882e5ae8
https://doi.org/10.1016/j.bmc.2023.117352
https://doi.org/10.1016/j.bmc.2023.117352
Autor:
Haobin Li, Maohua Cai, Fei Cao, Dehua Yu, Jing Yang, Wenkai Yu, Chu Chu, Xiaoqing Guan, Jiang-Jiang Qin, Jinyun Dong
Publikováno v:
Bioorganicmedicinal chemistry. 71
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of many human cancers and has been widely recognized as a promising target for cancer therapy. A variety of small-molecule inhibitors have been developed for targeting STAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92495559ed465b5e388c03070998933
https://pubmed.ncbi.nlm.nih.gov/35944386
https://pubmed.ncbi.nlm.nih.gov/35944386
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leading to a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54df9c50d4c0ddfe5534bc0e9430cf59
https://pubmed.ncbi.nlm.nih.gov/34488823
https://pubmed.ncbi.nlm.nih.gov/34488823
Publikováno v:
Acta Microscopica. 2019, Vol. 28 Issue 6, p1647-1653. 7p.