Zobrazeno 1 - 10
of 404
pro vyhledávání: '"Maode Lai"'
Autor:
Jingwen Deng, Shaoxia Liao, Chaoyi Chen, Fengyan Han, Siqin Lei, Xuan Lai, Kehong Ye, Qizheng Han, Fang E, Chao Lu, Maode Lai, Fanlong Liu, Honghe Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. However, whether tumor-driving circRNAs can
Externí odkaz:
https://doaj.org/article/ce8f82a4d54b471db7f191f54ec1347e
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3181-3207 (2023)
Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which regulate splice site recognition and spliceosome assembly during precursor messenger RNA splicing. SRSFs also participate in other RNA metabolic events, such as
Externí odkaz:
https://doaj.org/article/98344555a74d4699bbee7b5b8b747a9a
Autor:
Siqin Lei, Chaoyi Chen, Fengyan Han, Jingwen Deng, Dongdong Huang, Lili Qian, Ming Zhu, Xiaohui Ma, Maode Lai, Enping Xu, Honghe Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113110- (2023)
Summary: The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. AMER1 loss causes resistance to ferroptosis in colorectal cancer (CRC) cells. Interestingly, AMER1-deficient
Externí odkaz:
https://doaj.org/article/efe51dd862804c759f06b382eb3958ce
Autor:
Chaoyi Chen, Hongfei Yu, Fengyan Han, Xuan Lai, Kehong Ye, Siqin Lei, Minglang Mai, Maode Lai, Honghe Zhang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background & Aims To clarify the biological roles, circularization process and secretion pathway of circRHOBTB3 in colorectal cancer (CRC) progression. Methods We performed a comprehensive analysis of circRNA levels in serum exosomes from mu
Externí odkaz:
https://doaj.org/article/13d98dd752264a3cb3f6103d22446079
Autor:
Qiong Wu, Jiankang Li, Jinghan Zhu, Xiaohui Sun, Di He, Jun Li, Zongxue Cheng, Xuhui Zhang, Yuying Xu, Qing Chen, Yimin Zhu, Maode Lai
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
ObjectiveGamma-glutamyl dipeptides are bioactive peptides involved in inflammation, oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has been extensively reported to be associated with the risk of cardio-metabolic dise
Externí odkaz:
https://doaj.org/article/1d42879cc1a740b2bb914041dc02d08d
Autor:
Si Li, Jun Zhang, Senmi Qian, Xuesong Wu, Liang Sun, Tianyi Ling, Yao Jin, Wenxiao Li, Lichao Sun, Maode Lai, Fangying Xu
Publikováno v:
Cancer Communications, Vol 41, Iss 2, Pp 154-170 (2021)
Abstract Background The transforming growth factor‐β (TGF‐β) pathway plays a pivotal role in inducing epithelial‐mesenchymal transition (EMT), which is a key step in cancer invasion and metastasis. However, the regulatory mechanism of TGF‐
Externí odkaz:
https://doaj.org/article/ff6dfe52565344ec9270ad265b67dc9c
Publikováno v:
Metabolites, Vol 13, Iss 3, p 451 (2023)
2-hydroxybutyric acid (2HB) serves as an important regulatory factor in a variety of diseases. The circulating level of 2HB in serum is significantly higher in multiple diseases, such as cancer and type 2 diabetes (T2D). However, there is currently n
Externí odkaz:
https://doaj.org/article/b3f15301443d45e78c5afd1adece6e92
Autor:
Xiaoqing Cheng, Fenglan Zhang, Jingwen Gong, Yige Li, Dan Zhou, Jing Wang, Eu Gene Vong, Ying Yuan, Maode Lai, Dandan Zhang
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010050 (2022)
Genome-wide association studies (GWAS) have identified more than 160 susceptibility loci for colorectal cancer (CRC). The effects of these variants, particularly their mechanisms, however, remain unclear. In this study, a comprehensive functional ann
Externí odkaz:
https://doaj.org/article/2474f26e109c409db1a8691b7613e024
Autor:
Qiong Wu, Jiankang Li, Xiaohui Sun, Di He, Zongxue Cheng, Jun Li, Xuhui Zhang, Yongming Xie, Yimin Zhu, Maode Lai
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103707- (2021)
Background: Metabolic syndrome (MetS) is a cluster of multiple cardiometabolic risk factors that increase the risk of type 2 diabetes and cardiovascular diseases. Identifying novel biomarkers of MetS and their genetic associations could provide insig
Externí odkaz:
https://doaj.org/article/21253ba40e1f4d57aa9656e1865a5273
Autor:
Chunwei Lv, Hongfei Yu, Keyi Wang, Chaoyi Chen, Jinlong Tang, Fengyan Han, Minglang Mai, Kehong Ye, Maode Lai, Honghe Zhang
Publikováno v:
Cells, Vol 11, Iss 15, p 2363 (2022)
The glycolytic enzyme enolase 2 (ENO2) is dysregulated in many types of cancer. However, the roles and detailed molecular mechanism of ENO2 in colorectal cancer (CRC) metastasis remain unclear. Here, we performed a comprehensive analysis of ENO2 expr
Externí odkaz:
https://doaj.org/article/66cc7310931f406691e312b31dd06554