Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug

Autor: Ping Wang, Dafei Xie, Xiaochang Liu, Yongqing Gu, Xingkun Ao, Xinxin Liang, Ziyan Yan, Yuhao Liu, Ping-Kun Zhou, Zheng Liu, Shanshan Gao, Duo Wang, Mao-Xiang Zhu

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11309, p 11309 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Understanding miRNAs regulatory roles in epithelial-mesenchymal transition (EMT) would help establish new avenues for further uncovering the mechanisms underlying radiation-induced pulmonary fibrosis (RIPF) and identifying preventative and therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49c9eef705b9aa9140fe7786d1f7548
https://pubmed.ncbi.nlm.nih.gov/34768749

Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats

Autor: Zhao Junwei, Long Xu, Limeng Wang, Xiujie Pan, Jianping Xie, Xing-yu Liu, Xiang Li, Mao-xiang Zhu, Zhi-hua Yang

Publikováno v: The Journal of Toxicological Sciences. 43:33-44

Crotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b259f21ce181bf4d448424dfd56b927
https://doi.org/10.2131/jts.43.33

LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease

Autor: Yuke Zhang, Mao-xiang Zhu, Qin Wang, Zhihua Yang, Xiujie Pan, Wei Xiao, Congcong Sun

Publikováno v: Laboratory Investigation. 94:991-1002

Emerging evidence suggests that the process of small airway remodeling is mediated by profibrotic growth factors produced by epithelium, which are capable of activating the underlying mesenchymal cells with excessive collagen production. It has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd81d442c263e4260a1ae4be2c2ae8d
https://doi.org/10.1038/labinvest.2014.86

Transcript profiling analysis of in vitro cultured THP-1 cells after exposure to crotonaldehyde

Autor: Li-meng Wang, Zhi-hua Yang, Mao-xiang Zhu, Xiujie Pan, Bi-cheng Yang, Jianping Xie, Xing-yu Liu

Publikováno v: The Journal of Toxicological Sciences. 39:487-497

Crotonaldehyde, a highly toxic alpha, beta-unsaturated aldehyde, is a major component of cigarette smoke and a ubiquitous environmental pollutant. crotonaldehyde exposure is known to have adverse effects on respiratory health, but the underlying mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56afcd92457d46b80ddfc10b64217d80
https://doi.org/10.2131/jts.39.487

Crotonaldehyde induces apoptosis and immunosuppression in alveolar macrophages

Autor: Xiujie Pan, Jianping Xie, Zhi-hua Yang, Mao-xiang Zhu, Xing-yu Liu, Bi-cheng Yang

Publikováno v: Toxicology in Vitro. 27:128-137

Crotonaldehyde, a highly toxic α, β-unsaturated aldehyde, is a major component of cigarette smoke (CS) and a ubiquitous environmental pollutant. Exposure to crotonaldehyde-rich pollutants such as CS is associated with suppression of respiratory hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e11ac61e42f937ddcfd6e394045609e
https://doi.org/10.1016/j.tiv.2012.09.008