Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mao-Fu Sun"'
Autor:
Aleksandr Shamanaev, S. Kent Dickeson, Ivan Ivanov, Maxim Litvak, Mao-Fu Sun, Sunil Kumar, Quifang Cheng, Priyanka Srivastava, Tracey Z. He, David Gailani
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production. In most cases, dysregulation of the plasma kallikrein-kinin system due to deficiency of plasma C1 in
Externí odkaz:
https://doaj.org/article/28f5954b9ff34014889bcba98c57971e
Autor:
Shamanaev, Aleksandr, Dickeson, S. Kent, Ivanov, Ivan, Litvak, Maxim, Mao-Fu Sun, Kumar, Sunil, Quifang Cheng, Srivastava, Priyanka, He, Tracey Z., Gailani, David
Publikováno v:
Frontiers in Physiology; 2023, p1-13, 13p
Autor:
S. Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M. Mohammed, Dennis R. Phillips, James C. Whisstock, Adam J. Quek, Edward P. Feener, Ruby H. P. Law, David Gailani
Publikováno v:
Blood
Patients with hereditary angioedema (HAE) experience episodes of bradykinin (BK)-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1 inhibitor, the main regulator of the proteases plasma kallikrein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fb565810b9d00d51524469e20cd25d
https://europepmc.org/articles/PMC9074402/
https://europepmc.org/articles/PMC9074402/
Autor:
Qiufang Cheng, Bassem M Mohammed, David Gailani, Anton Matafonov, Mao-fu Sun, Ingrid M. Verhamme, Kusumam Joseph, Allen P. Kaplan, Ivan B. Ivanov, S. Kent Dickeson
Publikováno v:
Blood. 135:558-567
Prekallikrein (PK) is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts the protease precursor factor XII (FXII) to the enzyme FXIIa. PK and FXII undergo reciprocal convers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702640eaddc9e73c2250376d1de584fb
https://doi.org/10.1182/blood.2019002224
https://doi.org/10.1182/blood.2019002224
Autor:
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M. Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M. Verhamme, Owen J. T. McCarty, Ruby H. P. Law, David Gailani
Publikováno v:
Blood advances. 6(10)
Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma kallikrein (PKa). FXII conversion to FXIIa by autocatalysis or PKa-mediated cleavage is enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cc62a075c3f464d635dc76d05ed032
https://pubmed.ncbi.nlm.nih.gov/35086137
https://pubmed.ncbi.nlm.nih.gov/35086137
Autor:
Andras Gruber, Mao Fu Sun, Christian J. Kastrup, Priyanka Srivastava, Jonas Emsley, S. Kent Dickeson, David Gailani, Alec LaPlace, Aleksandr Shamanaev, Michal B. Ponczek
Publikováno v:
Blood Adv
Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a component, along with prekallikr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5a5a41ca88bd61dd4927cc4f7ceee6
https://pubmed.ncbi.nlm.nih.gov/33351111
https://pubmed.ncbi.nlm.nih.gov/33351111
Autor:
S. Kent Dickeson, Andras Gruber, David Gailani, Ivan Ivanov, Mao Fu Sun, Anton Matafonov, Ingrid M. Verhamme, Suman Kundu, Bassem M. Mohammed, Keith R. McCrae, Qiufang Cheng
Publikováno v:
Blood. 133(10)
The plasma proteins factor XII (FXII) and prekallikrein (PK) undergo reciprocal activation to the proteases FXIIa and kallikrein by a process that is enhanced by surfaces (contact activation) and regulated by the serpin C1 inhibitor. Kallikrein cleav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af23edaf48740f9ff01f471bfd6e333e
https://pubmed.ncbi.nlm.nih.gov/30846509
https://pubmed.ncbi.nlm.nih.gov/30846509
Autor:
Mao-fu Sun, Ivan Ivanov, Rebecca S. Woodruff, David Gailani, Bruce A. Sullenger, Ingrid M. Verhamme
Publikováno v:
Thrombosis research. 156
Background The plasma protease factor XIa (FXIa) has become a target of interest for therapeutics designed to prevent or treat thrombotic disorders. Methods We used a solution-based, directed evolution approach called systematic evolution of ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9581b79ce3222b548a1967cbac4ae
https://pubmed.ncbi.nlm.nih.gov/28739204
https://pubmed.ncbi.nlm.nih.gov/28739204
Autor:
John P. Sheehan, Mao-fu Sun, Yipeng Geng, David Gailani, Qiufang Cheng, James H. Morrissey, Ingrid M. Verhamme, Stephanie A. Smith
Publikováno v:
Journal of Thrombosis and Haemostasis. 11:2020-2028
Summary Background Conversion of factor XI (FXI) to FXIa is enhanced by polymers of inorganic phosphate (polyP). This process requires FXI to bind to polyP. Each FXIa subunit contains anion-binding sites (ABSs) on the apple 3 (A3) and catalytic domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef8cb6f6d96a321053af15b0f38bf47
https://doi.org/10.1111/jth.12414
https://doi.org/10.1111/jth.12414
Autor:
Qiufang Cheng, Jonas Emsley, Anton Matafonov, Ingrid M. Verhamme, Ivan Ivanov, Mao-fu Sun, S. Kent Dickeson, David Gailani
Publikováno v:
Blood. 129(11)
When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe81d53d0b63dde0e05eab5b62b501d
https://pubmed.ncbi.nlm.nih.gov/28302690
https://pubmed.ncbi.nlm.nih.gov/28302690