Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Mao-Chin Liu"'
Autor:
Mei-Zhen Luo, Rui Zhu, Krishnamurthy Shyam, Raymond P. Baumann, Philip G. Penketh, Mao-Chin Liu, Alan C. Sartorelli
Publikováno v:
Journal of Medicinal Chemistry. 54:7720-7728
A series of 4-nitrobenzyloxycarbonyl prodrug derivatives of O(6)-benzylguanine (O(6)-BG), conceived as prodrugs of O(6)-BG, an inhibitor of the resistance protein O(6)-alkylguanine-DNA alkyltransferase (AGT), were synthesized and evaluated for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d795e4879742316731a8bbc1b0901940
https://doi.org/10.1021/jm201115f
https://doi.org/10.1021/jm201115f
Autor:
Marcello Forconi, Raghuvir N. Sengupta, Mao-Chin Liu, Alan C. Sartorelli, Joseph A. Piccirilli, Daniel Herschlag
Publikováno v:
Angewandte Chemie. 121:7307-7311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0809dd6d78324d43a34433d3eb5c2a7f
https://doi.org/10.1002/ange.200903006
https://doi.org/10.1002/ange.200903006
Autor:
Mao-Chin Liu, Mei-Zhen Luo, Diane Mozdziesz, Ginger Dutschman, Elizabeth Gullen, Yung-Chi Cheng, Alan Sartorelli
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 24:135-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f369d778191bc85802a380bf1e73eaf
https://doi.org/10.1081/ncn-200051898
https://doi.org/10.1081/ncn-200051898
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 24:45-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d7e874c68deb02818367f7fa11e262
https://doi.org/10.1081/ncn-200046784
https://doi.org/10.1081/ncn-200046784
Publikováno v:
Synthetic Communications. 32:3797-3802
A new, improved synthesis of 9-deazaguanine is described. The method involves use of the benzyloxymethyl group to protect the N 3-position of 2-[(dimethylaminomethylene)- amino]-6-methyl-5-nitro-4(3H)-pyrimidinone, followed by treatment with DMF-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cfad65ae20f7db6988f9b8b2596874
https://doi.org/10.1081/scc-120015398
https://doi.org/10.1081/scc-120015398
Autor:
Yung-Chi Cheng, Alan C. Sartorelli, Diane E. Mozdziesz, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Elizabeth A. Gullen, Mei-Zhen Luo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2145-2148
Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da6ac5fbf3da14e732fbb439f25ae8
https://doi.org/10.1016/s0960-894x(00)00418-2
https://doi.org/10.1016/s0960-894x(00)00418-2
Autor:
Mao-Chin Liu, Mei-Zhen Luo, Diane E. Mozdziesz, Tai-Shun Lin, Ginger E., null Dutschman, Yung-Chi Cheng, Alan C. Sartorelli
Publikováno v:
Nucleosides and Nucleotides. 18:55-72
2'-Deoxy-2'-methylene-6-azauridine (5) and 2'-deoxy-2'-methylene-6-azacytidine (8) have been synthesized via a multi-step procedure from 6-azauridine. 2'-Deoxy-2'-methylene-5-azacytidine (14a) and 2'-deoxy-2'-methylene-3-deazaguanosine (19a) and thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960316c1c62c6ac7d142efcd6a39e60f
https://doi.org/10.1080/07328319908045594
https://doi.org/10.1080/07328319908045594
Autor:
Ju-Liang Zhu, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Yung-Chi Cheng, Yimei Zhu, Mei-Zhen Luo
Publikováno v:
Nucleosides and Nucleotides. 14:1759-1783
Various 2′,3′-dideoxy-L-nucleoside analogues, 6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl) purine (19), 2-chloro-6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl)-purine (20), 2-chloro-6-amino-9-(2,3-dideoxy-4-thio-β-L-ribofuranosyl) purine (21), 2,6-dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22b28d4d6c15985348be4cb5d27f0f5
https://doi.org/10.1080/15257779508009755
https://doi.org/10.1080/15257779508009755
Autor:
Mao-Chin Liu, Yong-Lian Zhu, Ginger E. Dutschman, S. Balakrishna Pai, Tai-Shun Lin, Mei-Zhen Luo, Yung-Chi Cheng, Mao-Mi Li, Xin Guo
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:619-625
The pharmacokinetics and toxicology of 2′,3′-dideoxy-β-L-5-fluorocytidine (β-L-FddC) and 2′,3′-dideoxy-β-L-cytidine (β-L-ddC) in mice was investigated. In addition, 2′,3′-dideoxy-β-L-5-azacytidine (β-L-5-aza-ddC) and its α-L-anomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b067bc1127fc844c189693eda9d8668
https://doi.org/10.1080/15257779508012438
https://doi.org/10.1080/15257779508012438
Autor:
Alan C. Sartorelli, Aurelio Lorico, Joseph G. Cory, Germana Rappa, Tai-Shun Lin, Ann H. Cory, Mao-Chin Liu
Publikováno v:
Biochemical Pharmacology. 48:335-344
A new series of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones (HCTs) was studied for their effects on L1210 cell growth in culture, cell cycle transit, nucleic acid biosynthesis and ribonucleotide reductase activity. 3-Aminopyridine-2-carboxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f6bb9864a174a5f904dd4bfe397e45
https://doi.org/10.1016/0006-2952(94)90105-8
https://doi.org/10.1016/0006-2952(94)90105-8