Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mao Hori"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Controlled assembly of a protein shell around a viral genome is a key step in the life cycle of many viruses. Here we report a strategy for regulating the co-assembly of nonviral proteins and nucleic acids into highly ordered nucleocapsids i
Externí odkaz:
https://doaj.org/article/8ab1e706351f47f6be1bb2f936f1c2fc
Autor:
Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida
Publikováno v:
Small Science, Vol 4, Iss 4, Pp n/a-n/a (2024)
Organ‐selective targeting of mRNA polyplexes has been rarely explored despite the substantial potential of polymer‐based systems in mRNA delivery. In this study, spleen‐selective delivery of polyplexes is achieved by employing mRNA engineering
Externí odkaz:
https://doaj.org/article/fe7bde1132c74192b0fb44db21d9b503
Autor:
Thomas G. W. Edwardson, Mikail D. Levasseur, Stephan Tetter, Angela Steinauer, Mao Hori, Donald Hilvert
Publikováno v:
Chemical Reviews, 122 (9)
Proteins that self-assemble into polyhedral shell-like structures are useful molecular containers both in nature and in the laboratory. Here we review efforts to repurpose diverse protein cages, including viral capsids, ferritins, bacterial microcomp
Autor:
Mao Hori, Kotaro Hayashi, Akihiro Kishimura, Tetsuya Nagata, Yasutaka Anraku, Kazunori Kataoka, Yu Yi, Kanjiro Miyata, Beob Soo Kim, Mitsuru Naito, Hyun Su Min, Hyun Jin Kim, Hiroyuki Chaya
Publikováno v:
Biomacromolecules. 21:4365-4376
For the simultaneous delivery of antisense oligonucleotides and their effector enzymes into cells, nanosized vesicular polyion complexes (PICs) were fabricated from oppositely charged polyion-pairs of oligonucleotides and poly(ethylene glycol) (PEG)-
Autor:
Beob Soo, Kim, Mitsuru, Naito, Hiroyuki, Chaya, Mao, Hori, Kotaro, Hayashi, Hyun Su, Min, Yu, Yi, Hyun Jin, Kim, Tetsuya, Nagata, Yasutaka, Anraku, Akihiro, Kishimura, Kazunori, Kataoka, Kanjiro, Miyata
Publikováno v:
Biomacromolecules. 21(10)
For the simultaneous delivery of antisense oligonucleotides and their effector enzymes into cells, nanosized vesicular polyion complexes (PICs) were fabricated from oppositely charged polyion pairs of oligonucleotides and poly(ethylene glycol) (PEG)
Publikováno v:
Biomacromolecules. 19:4113-4121
Polyion complex vesicles (PICsomes) formed from a self-assembly of an oppositely charged pair of block- and homo-polyelectrolytes have shown exceptional features for functional loading of bioactive agents. Nevertheless, the stability of PICsomes is o
Autor:
Kensuke Osada, Kazunori Kataoka, Mitsuru Naito, Yu Yi, Yu Fukusato, Mao Hori, Yasutaka Anraku, Takao Jinbo, Seiji Takae, Takehiko Ishii, Kanjiro Miyata
Publikováno v:
Chemical Communications. 52:1517-1519
Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. The decoration with sufficiently shorter PEGs dramatically enhanced t
Autor:
Rimpei Kamegawa, Shigehito Osawa, Hyun Jin Kim, Hiroyasu Takemoto, Mitsuru Naito, Takehiko Ishii, Nobuhiro Nishiyama, Kazunori Kataoka, Naoto Yoshinaga, Mao Hori, Ryota Azuma, Kanjiro Miyata
Surface functionalization of nanoparticles is a crucial factor for nanoparticle-mediated drug and nucleic acid delivery. Particularly, the density of targeting ligands on nanoparticle significantly affects the affinity of nanoparticles to specific ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e31c5c47067599f2f55f8f9fa8803c
Publikováno v:
Biomacromolecules. 15(7)
Integrating catalytic functions into polymeric vesicles through enzyme entrapment is appealing for bioreactor fabrication, yet there are critical issues regarding the regulation of solute transport through membranes and enzyme loading without denatur
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35494 (2012)
BackgroundThe N-methyl-D-aspartate (NMDA) receptors play a role in behavioral abnormalities observed after administration of the psychostimulant, methamphetamine (METH). Serine racemase (SRR) is an enzyme which synthesizes D-serine, an endogenous co-
Externí odkaz:
https://doaj.org/article/9307bc56b24547a3a3eb1b32800dff58