Drugst.One -- A plug-and-play solution for online systems medicine and network-based drug repurposing

Autor: Maier, Andreas, Hartung, Michael, Abovsky, Mark, Adamowicz, Klaudia, Bader, Gary D., Baier, Sylvie, Blumenthal, David B., Chen, Jing, Elkjaer, Maria L., Garcia-Hernandez, Carlos, Helmy, Mohamed, Hoffmann, Markus, Jurisica, Igor, Kotlyar, Max, Lazareva, Olga, Levi, Hagai, List, Markus, Lobentanzer, Sebastian, Loscalzo, Joseph, Malod-Dognin, Noel, Manz, Quirin, Matschinske, Julian, Mee, Miles, Oubounyt, Mhaned, Pico, Alexander R., Pillich, Rudolf T., Poschenrieder, Julian M., Pratt, Dexter, Pržulj, Nataša, Sadegh, Sepideh, Saez-Rodriguez, Julio, Sarkar, Suryadipto, Shaked, Gideon, Shamir, Ron, Trummer, Nico, Turhan, Ugur, Wang, Ruisheng, Zolotareva, Olga, Baumbach, Jan

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerg

Externí odkaz: http://arxiv.org/abs/2305.15453

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systematic comparison of novel and existing differential analysis methods for CyTOF data.

Autor: Arend, Lis, Bernett, Judith, Manz, Quirin, Klug, Melissa, Lazareva, Olga, Baumbach, Jan, Bongiovanni, Dario, List, Markus

Publikováno v: Briefings in Bioinformatics; Jan2022, Vol. 23 Issue 1, p1-12, 12p

Drugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.

Autor: Maier A; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Hartung M; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Abovsky M; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada., Adamowicz K; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Baier S; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Blumenthal DB; Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany., Chen J; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Elkjaer ML; Department of Neurology, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Garcia-Hernandez C; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain., Helmy M; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada., Hoffmann M; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Institute for Advanced Study (Lichtenbergstrasse 2a, D-85748 Garching, Germany), Technical University of Munich, Germany.; National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America., Jurisica I; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada.; Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Kotlyar M; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada., Lazareva O; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Junior Clinical Cooperation Unit Multiparametric methods for early detection of prostate cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany., Levi H; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., List M; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Lobentanzer S; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany., Loscalzo J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Malod-Dognin N; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain., Manz Q; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Matschinske J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Mee M; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada., Oubounyt M; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Pico AR; Institute of Data Science and Biotechnology, Gladstone Institutes, 1650 Owens Street, San Francisco, 94158, California, USA., Pillich RT; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Poschenrieder JM; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Pratt D; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Pržulj N; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.; Department of Computer Science, University College London, London WC1E 6BT, UK.; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain., Sadegh S; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany., Sarkar S; Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany., Shaked G; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., Shamir R; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., Trummer N; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Turhan U; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Wang R; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zolotareva O; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Baumbach J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Computational Biomedicine Lab, Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.

Publikováno v: ArXiv [ArXiv] 2023 Jul 04. Date of Electronic Publication: 2023 Jul 04.