Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Manxia Fan"'
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Long-term survivors of human immunodeficiency virus (HIV) infection have been shown to have a greatly increased incidence of B cell lymphomas. This increased lymphomagenesis suggests some link between HIV infection and the destabilization of
Externí odkaz:
https://doaj.org/article/b0a442bfc9924af8849b9674fcf5263a
Autor:
Linda B. Baughn, Susan L. Kalis, Thomas MacCarthy, Lirong Wei, Manxia Fan, Aviv Bergman, Matthew D. Scharff
Publikováno v:
mBio, Vol 2, Iss 5 (2011)
ABSTRACT Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody respon
Externí odkaz:
https://doaj.org/article/5cc1e766bcb347778226b18dc0279ba3
Autor:
Jacqueline C. Barrientos, Nicholas Chiorazzi, Jose A. Martinez-Climent, Marien Pascual, Kanti R. Rai, Matthew D. Scharff, Xiao-Jie Yan, Boris Bartholdy, Manxia Fan, Sergio Roa, Xiahoua Wang, Steven L. Allen
Publikováno v:
Blood advances. 4(5)
Intraclonal subpopulations of circulating chronic lymphocytic leukemia (CLL) cells with different proliferative histories and reciprocal surface expression of CXCR4 and CD5 have been observed in the peripheral blood of CLL patients and named prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4862c6ee7bb0ddf2ebe4d2ecf3f166e2
https://pubmed.ncbi.nlm.nih.gov/32150608
https://pubmed.ncbi.nlm.nih.gov/32150608
Publikováno v:
Journal of Immunological Methods. 316:59-66
Monoclonal antibodies are used in the treatment and diagnosis of diseases and to study the protective and adverse functions of antibodies in vitro and in vivo. Since the isotype determines the effector function, half-life in the serum and distributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92313c98b4bdf684bb1fe5ae60792253
https://doi.org/10.1016/j.jim.2006.08.002
https://doi.org/10.1016/j.jim.2006.08.002
Publikováno v:
Carcinogenesis. 17:1519-1526
A pharmacogenetic mouse model was utilized to determine the role of Cyplal expression on the formation of Ki-ras mutations in lung tumors following transplacental exposure to polycyclic aromatic hydrocarbons (PAHs). A backcross between Ah responsive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4adffb19f4c40ec5979b027cd4aaeaca
https://doi.org/10.1093/carcin/17.7.1519
https://doi.org/10.1093/carcin/17.7.1519
Autor:
Leal Herlitz, Kui Liu, Chaim Putterman, Manxia Fan, Anna Broder, Rahul D. Pawar, Ling Wang, Yumin Xia, Beatrice Goilav, Antonio Nakouzi, Arturo Casadevall, Quan Zhen Li
Publikováno v:
Journal of autoimmunity. 39(4)
Affinity for DNA and cross-reactivity with renal antigens are associated with enhanced renal pathogenicity of lupus autoantibodies. In addition, certain IgG subclasses are enriched in nephritic kidneys, suggesting that isotype may determine the outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2972d61e99c23a7c852b6b535414d80a
https://pubmed.ncbi.nlm.nih.gov/22841793
https://pubmed.ncbi.nlm.nih.gov/22841793
Autor:
Manxia Fan, Linda B. Baughn, Aviv Bergman, Lirong Wei, Susan L. Kalis, Matthew D. Scharff, Thomas MacCarthy
Publikováno v:
mBio
mBio, Vol 2, Iss 5 (2011)
mBio, Vol 2, Iss 5 (2011)
Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody response agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb38ee5ac6945f323231652ae1053fd
https://doi.org/10.1128/mbio.00186-11
https://doi.org/10.1128/mbio.00186-11
Autor:
Manxia Fan, Arturo Casadevall
Publikováno v:
The Journal of General and Applied Microbiology. 38:491-495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22340f0ddb5adf00c0e90bcf112f789f
https://doi.org/10.2323/jgam.38.491
https://doi.org/10.2323/jgam.38.491
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(33)
To create high-affinity antibodies, B cells target a high rate of somatic hypermutation (SHM) to the Ig variable-region genes that encode the antigen-binding site. This mutational process requires transcription and is triggered by activation-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f53dec7c87e3104f4522bc9e330f8c
https://pubmed.ncbi.nlm.nih.gov/16087866
https://pubmed.ncbi.nlm.nih.gov/16087866
Autor:
Marc J. Shulman, Matthew D. Scharff, Caroline J. Woo, Manxia Fan, Philip Bardwell, Alberto Martin
Publikováno v:
Nature. 415(6873)
The production of high-affinity protective antibodies requires somatic hypermutation (SHM) of the antibody variable (V)-region genes. SHM is characterized by a high frequency of point mutations that occur only during the centroblast stage of B-cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208a2541148d53c35cdf0a070d8da6e0
https://pubmed.ncbi.nlm.nih.gov/11823785
https://pubmed.ncbi.nlm.nih.gov/11823785