Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Manvendra K. Singh"'
Autor:
Huimei Chen, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Kevin Y. Huang, Jing Guo, Shiyang Liu, Elisabeth Li Sa Tan, Shuang Chen, Nicole Gui Zhen Tee, Masum M. Mia, Manvendra K. Singh, Aihua Zhang, Jacques Behmoaras, Enrico Petretto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocy
Externí odkaz:
https://doaj.org/article/04ab9cd1a1a34c4da30eb9e5180335f7
Autor:
Masum M. Mia, Manvendra K. Singh
Publikováno v:
Cells, Vol 11, Iss 13, p 2065 (2022)
Fibrosis results from defective wound healing processes often seen after chronic injury and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent organ damage/failure. The hallmark of fibrosis is the excessive accumu
Externí odkaz:
https://doaj.org/article/6fc6af9160804e7b9bcc961f2f31d4fc
Autor:
Kazuaki Maruyama, Kazuaki Naemura, Yuichiro Arima, Yasunobu Uchijima, Hiroaki Nagao, Kenji Yoshihara, Manvendra K. Singh, Akiyoshi Uemura, Fumio Matsuzaki, Yutaka Yoshida, Yukiko Kurihara, Sachiko Miyagawa-Tomita, Hiroki Kurihara
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102305- (2021)
Summary: Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aorti
Externí odkaz:
https://doaj.org/article/b38903fdfe96445f8df53c27264b41b4
Autor:
Dasan Mary Cibi, Kathleen Wung Bi-Lin, Shamini Guna Shekeran, Reddemma Sandireddy, Nicole Tee, Anamika Singh, Yajun Wu, Dinesh Kumar Srinivasan, Jean-Paul Kovalik, Sujoy Ghosh, Patrick Seale, Manvendra K. Singh
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108288- (2020)
Summary: Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response to physiological or pathological stress, prolonged hypertrophy
Externí odkaz:
https://doaj.org/article/1aade85b19c14a27ac9367841f5fd88b
Autor:
Masum M. Mia, Manvendra K. Singh
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, lo
Externí odkaz:
https://doaj.org/article/b42819c25a044e379449db641bcbca42
Autor:
Mao Wang, Patrick Sips, Ester Khin, Maxime Rotival, Ximing Sun, Rizwan Ahmed, Anissa Anindya Widjaja, Sebastian Schafer, Permeen Yusoff, Pervinder Kaur Choksi, Nicole Shi Jie Ko, Manvendra K. Singh, David Epstein, Yuguang Guan, Josef Houštěk, Tomas Mracek, Hana Nuskova, Brittney Mikell, Jessie Tan, Francesco Pesce, Frantisek Kolar, Leonardo Bottolo, Massimiliano Mancini, Norbert Hubner, Michal Pravenec, Enrico Petretto, Calum MacRae, Stuart A Cook
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel gr
Externí odkaz:
https://doaj.org/article/550ec9cd37e7417c90bb6b8603a4479c
Autor:
Anamika Singh, Sindhu Ramesh, Dasan Mary Cibi, Lim Sze Yun, Jun Li, Li Li, Lauren J. Manderfield, Eric N. Olson, Jonathan A. Epstein, Manvendra K. Singh
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1384-1393 (2016)
Summary: Formation of the coronary vasculature is a complex and precisely coordinated morphogenetic process that begins with the formation of epicardium. The epicardium gives rise to many components of the coronary vasculature, including fibroblasts,
Externí odkaz:
https://doaj.org/article/841b1b1362cf4469b2ce51308957b7db
Publikováno v:
Journal of Developmental Biology, Vol 1, Iss 2, Pp 141-158 (2013)
The death of cardiac myocytes resulting from myocardial infarction is a major cause of heart failure worldwide. Effective therapies for regenerating lost cardiac myocytes are lacking. Recently, the epicardium has been implicated as a source of inflam
Externí odkaz:
https://doaj.org/article/5968f62907bf49f1bbe290def38c996e
Autor:
Young Il Choi, Jonathan S Duke-Cohan, Jing eTan, Jingang eGui, Manvendra K. Singh, Jonathan A Epstein, Ellis L Reinherz
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
An important role for plexinD1 in thymic development is inferred from studies of germline Plxnd1 knockout (KO) mice where mislocalized CD69+ thymocytes as well as ectopic thymic subcapsular medullary structures were observed. Given embryonic lethalit
Externí odkaz:
https://doaj.org/article/15e8cbe51ed5449ea93f85a799ba0679
Autor:
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Publikováno v:
Journal of Hepatology. 77:1246-1255